The ALLgorithMM: How to define the hemodilution of bone marrow samples in lymphoproliferative diseases

The ALLgorithMM: How to define the hemodilution of bone marrow samples in lymphoproliferative diseases

IntroductionMinimal residual disease (MRD) is commonly assessed in bone marrow (BM) aspirate. However, sample quality can impair the MRD measurement, leading to underestimated residual cells and to false negative results. To define a reliable and reproducible method for the assessment of BM hemodilu...

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Main Authors: Ilaria Vigliotta, Silvia Armuzzi, Martina Barone, Vincenza Solli, Ignazia Pistis, Enrica Borsi, Barbara Taurisano, Gaia Mazzocchetti, Marina Martello, Andrea Poletti, Chiara Sartor, Ilaria Rizzello, Lucia Pantani, Paola Tacchetti, Cristina Papayannidis, Katia Mancuso, Serena Rocchi, Elena Zamagni, Antonio Curti, Mario Arpinati, Michele Cavo, Carolina Terragna
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
minimal residual disease
multiple myeloma
acute lymphoblastic leukemia
hemodilution
hemodilution/methods
flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1001048/full

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