Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease
Background A comprehensive visual rating scale (CVRS) using brain magnetic resonance imaging (MRI) was previously developed to evaluate structural changes in the brains of older patients. This study investigated the usefulness of the CVRS in predicting dementia with Alzheimer disease (AD) in patient...
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| Format: | Article |
| Language: | English |
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Korea Geriatrics Society
2021-03-01
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| Series: | Annals of Geriatric Medicine and Research |
| Subjects: | |
| Online Access: | http://www.e-agmr.org/upload/pdf/agmr-21-0010.pdf |
| _version_ | 1818728332266569728 |
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| author | Jae Kyung Chung Jae-Won Jang |
| author_facet | Jae Kyung Chung Jae-Won Jang |
| author_sort | Jae Kyung Chung |
| collection | DOAJ |
| description | Background A comprehensive visual rating scale (CVRS) using brain magnetic resonance imaging (MRI) was previously developed to evaluate structural changes in the brains of older patients. This study investigated the usefulness of the CVRS in predicting dementia with Alzheimer disease (AD) in patients with prodromal AD. Methods We included 189 patients with prodromal AD with available data from the Alzheimer’s Disease Neuroimaging Initiative study. We evaluated all patients using CVRS and assessed their progression to AD dementia over 3 years of longitudinal follow-up. Survival analysis was performed using the Cox proportional hazards model to analyze the hazard ratios of the CVRS for progression to AD dementia. Results Among 189 patients with prodromal AD, 61 (32.3%) progressed to dementia. The mean baseline CVRS scores differed significantly between the stable and progressive groups (9.9±5.1 vs. 12.4±4.9; p=0.002). An initial high CVRS score was an independent risk factor for the progression to AD dementia (hazard ratio=1.110; 95% confidence interval, 1.043–1.182). Conclusion The baseline CVRS score predicted the progression to dementia in patients with prodromal AD, indicating its independent association with longitudinal cognitive decline. |
| first_indexed | 2024-12-17T22:28:18Z |
| format | Article |
| id | doaj.art-45fc49977f4d4a41af64eb14ff814073 |
| institution | Directory Open Access Journal |
| issn | 2508-4798 2508-4909 |
| language | English |
| last_indexed | 2024-12-17T22:28:18Z |
| publishDate | 2021-03-01 |
| publisher | Korea Geriatrics Society |
| record_format | Article |
| series | Annals of Geriatric Medicine and Research |
| spelling | doaj.art-45fc49977f4d4a41af64eb14ff8140732022-12-21T21:30:17ZengKorea Geriatrics SocietyAnnals of Geriatric Medicine and Research2508-47982508-49092021-03-01251394410.4235/agmr.21.0010959Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer DiseaseJae Kyung Chung0Jae-Won Jang1 Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea Department of Neurology, Kangwon National University Hospital, Chuncheon, KoreaBackground A comprehensive visual rating scale (CVRS) using brain magnetic resonance imaging (MRI) was previously developed to evaluate structural changes in the brains of older patients. This study investigated the usefulness of the CVRS in predicting dementia with Alzheimer disease (AD) in patients with prodromal AD. Methods We included 189 patients with prodromal AD with available data from the Alzheimer’s Disease Neuroimaging Initiative study. We evaluated all patients using CVRS and assessed their progression to AD dementia over 3 years of longitudinal follow-up. Survival analysis was performed using the Cox proportional hazards model to analyze the hazard ratios of the CVRS for progression to AD dementia. Results Among 189 patients with prodromal AD, 61 (32.3%) progressed to dementia. The mean baseline CVRS scores differed significantly between the stable and progressive groups (9.9±5.1 vs. 12.4±4.9; p=0.002). An initial high CVRS score was an independent risk factor for the progression to AD dementia (hazard ratio=1.110; 95% confidence interval, 1.043–1.182). Conclusion The baseline CVRS score predicted the progression to dementia in patients with prodromal AD, indicating its independent association with longitudinal cognitive decline.http://www.e-agmr.org/upload/pdf/agmr-21-0010.pdfmagnetic resonance imagingalzheimer diseasecognitive dysfunction |
| spellingShingle | Jae Kyung Chung Jae-Won Jang Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease Annals of Geriatric Medicine and Research magnetic resonance imaging alzheimer disease cognitive dysfunction |
| title | Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease |
| title_full | Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease |
| title_fullStr | Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease |
| title_full_unstemmed | Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease |
| title_short | Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease |
| title_sort | comprehensive visual rating scale on magnetic resonance imaging application to prodromal alzheimer disease |
| topic | magnetic resonance imaging alzheimer disease cognitive dysfunction |
| url | http://www.e-agmr.org/upload/pdf/agmr-21-0010.pdf |
| work_keys_str_mv | AT jaekyungchung comprehensivevisualratingscaleonmagneticresonanceimagingapplicationtoprodromalalzheimerdisease AT jaewonjang comprehensivevisualratingscaleonmagneticresonanceimagingapplicationtoprodromalalzheimerdisease |