Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors
Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One prom...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/11/1007 |
| _version_ | 1797550088247050240 |
|---|---|
| author | Mohamadreza Amin Wenqiu Huang Ann L. B. Seynhaeve Timo L. M. ten Hagen |
| author_facet | Mohamadreza Amin Wenqiu Huang Ann L. B. Seynhaeve Timo L. M. ten Hagen |
| author_sort | Mohamadreza Amin |
| collection | DOAJ |
| description | Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials. |
| first_indexed | 2024-03-10T15:24:29Z |
| format | Article |
| id | doaj.art-45fc5c3376764eee820c9f0aabd10117 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T15:24:29Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-45fc5c3376764eee820c9f0aabd101172023-11-20T18:09:58ZengMDPI AGPharmaceutics1999-49232020-10-011211100710.3390/pharmaceutics12111007Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid TumorsMohamadreza Amin0Wenqiu Huang1Ann L. B. Seynhaeve2Timo L. M. ten Hagen3Laboratory of Experimental Oncology (LEO), Department of Pathology, Erasmus Medical Center, 3015GE Rotterdam, The NetherlandsLaboratory of Experimental Oncology (LEO), Department of Pathology, Erasmus Medical Center, 3015GE Rotterdam, The NetherlandsLaboratory of Experimental Oncology (LEO), Department of Pathology, Erasmus Medical Center, 3015GE Rotterdam, The NetherlandsLaboratory of Experimental Oncology (LEO), Department of Pathology, Erasmus Medical Center, 3015GE Rotterdam, The NetherlandsNanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials.https://www.mdpi.com/1999-4923/12/11/1007hyperthermiatemperature sensitive nanoparticlesliposomespolymeric nanoparticlestriggered drug release |
| spellingShingle | Mohamadreza Amin Wenqiu Huang Ann L. B. Seynhaeve Timo L. M. ten Hagen Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors Pharmaceutics hyperthermia temperature sensitive nanoparticles liposomes polymeric nanoparticles triggered drug release |
| title | Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors |
| title_full | Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors |
| title_fullStr | Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors |
| title_full_unstemmed | Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors |
| title_short | Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors |
| title_sort | hyperthermia and temperature sensitive nanomaterials for spatiotemporal drug delivery to solid tumors |
| topic | hyperthermia temperature sensitive nanoparticles liposomes polymeric nanoparticles triggered drug release |
| url | https://www.mdpi.com/1999-4923/12/11/1007 |
| work_keys_str_mv | AT mohamadrezaamin hyperthermiaandtemperaturesensitivenanomaterialsforspatiotemporaldrugdeliverytosolidtumors AT wenqiuhuang hyperthermiaandtemperaturesensitivenanomaterialsforspatiotemporaldrugdeliverytosolidtumors AT annlbseynhaeve hyperthermiaandtemperaturesensitivenanomaterialsforspatiotemporaldrugdeliverytosolidtumors AT timolmtenhagen hyperthermiaandtemperaturesensitivenanomaterialsforspatiotemporaldrugdeliverytosolidtumors |