The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth
Neurite loss is one of the cardinal features of neuronal injury. Apart from neuroprotection, reorganization of the lost neuronal network in the injured brain is necessary for the restoration of normal physiological functions. Neuritogenic activity of endogenous molecules in the brain such as nerve g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/6/6728 |
| _version_ | 1818230014952341504 |
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| author | Dong-Kug Choi Byung-Wook Kim Sushruta Koppula Hemant Kumar In-Su Kim Sandeep Vasant More |
| author_facet | Dong-Kug Choi Byung-Wook Kim Sushruta Koppula Hemant Kumar In-Su Kim Sandeep Vasant More |
| author_sort | Dong-Kug Choi |
| collection | DOAJ |
| description | Neurite loss is one of the cardinal features of neuronal injury. Apart from neuroprotection, reorganization of the lost neuronal network in the injured brain is necessary for the restoration of normal physiological functions. Neuritogenic activity of endogenous molecules in the brain such as nerve growth factor is well documented and supported by scientific studies which show innumerable compounds having neurite outgrowth activity from natural sources. Since the damaged brain lacks the reconstructive capacity, more efforts in research are focused on the identification of compounds that promote the reformation of neuronal networks. An abundancy of natural resources along with the corresponding activity profiles have shown promising results in the field of neuroscience. Recently, importance has also been placed on understanding neurite formation by natural products in relation to neuronal injury. Arrays of natural herbal products having plentiful active constituents have been found to enhance neurite outgrowth. They act synergistically with neurotrophic factors to promote neuritogenesis in the diseased brain. Therefore use of natural products for neuroregeneration provides new insights in drug development for treating neuronal injury. In this study, various compounds from natural sources with potential neurite outgrowth activity are reviewed in experimental models. |
| first_indexed | 2024-12-12T10:27:46Z |
| format | Article |
| id | doaj.art-45fd5c287aa34babb165c742ae67bcd4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T10:27:46Z |
| publishDate | 2012-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-45fd5c287aa34babb165c742ae67bcd42022-12-22T00:27:25ZengMDPI AGMolecules1420-30492012-06-011766728675310.3390/molecules17066728The Role of Bioactive Compounds on the Promotion of Neurite OutgrowthDong-Kug ChoiByung-Wook KimSushruta KoppulaHemant KumarIn-Su KimSandeep Vasant MoreNeurite loss is one of the cardinal features of neuronal injury. Apart from neuroprotection, reorganization of the lost neuronal network in the injured brain is necessary for the restoration of normal physiological functions. Neuritogenic activity of endogenous molecules in the brain such as nerve growth factor is well documented and supported by scientific studies which show innumerable compounds having neurite outgrowth activity from natural sources. Since the damaged brain lacks the reconstructive capacity, more efforts in research are focused on the identification of compounds that promote the reformation of neuronal networks. An abundancy of natural resources along with the corresponding activity profiles have shown promising results in the field of neuroscience. Recently, importance has also been placed on understanding neurite formation by natural products in relation to neuronal injury. Arrays of natural herbal products having plentiful active constituents have been found to enhance neurite outgrowth. They act synergistically with neurotrophic factors to promote neuritogenesis in the diseased brain. Therefore use of natural products for neuroregeneration provides new insights in drug development for treating neuronal injury. In this study, various compounds from natural sources with potential neurite outgrowth activity are reviewed in experimental models.http://www.mdpi.com/1420-3049/17/6/6728neurite outgrowthneuroregenerationneuritogenesisnatural moleculesneurodegeneration |
| spellingShingle | Dong-Kug Choi Byung-Wook Kim Sushruta Koppula Hemant Kumar In-Su Kim Sandeep Vasant More The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth Molecules neurite outgrowth neuroregeneration neuritogenesis natural molecules neurodegeneration |
| title | The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth |
| title_full | The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth |
| title_fullStr | The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth |
| title_full_unstemmed | The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth |
| title_short | The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth |
| title_sort | role of bioactive compounds on the promotion of neurite outgrowth |
| topic | neurite outgrowth neuroregeneration neuritogenesis natural molecules neurodegeneration |
| url | http://www.mdpi.com/1420-3049/17/6/6728 |
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