Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/5/1145 |
| _version_ | 1797568893342973952 |
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| author | Nesrine Mabrouk Silvia Ghione Véronique Laurens Stéphanie Plenchette Ali Bettaieb Catherine Paul |
| author_facet | Nesrine Mabrouk Silvia Ghione Véronique Laurens Stéphanie Plenchette Ali Bettaieb Catherine Paul |
| author_sort | Nesrine Mabrouk |
| collection | DOAJ |
| description | Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment. |
| first_indexed | 2024-03-10T20:03:19Z |
| format | Article |
| id | doaj.art-45fe0865965e47159b4977980dac78b0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T20:03:19Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-45fe0865965e47159b4977980dac78b02023-11-19T23:22:16ZengMDPI AGCancers2072-66942020-05-01125114510.3390/cancers12051145Senescence and Cancer: Role of Nitric Oxide (NO) in SASPNesrine Mabrouk0Silvia Ghione1Véronique Laurens2Stéphanie Plenchette3Ali Bettaieb4Catherine Paul5Laboratory of Immunology and Immunotherapy of Cancers, EPHE, PSL Research University, 75000 Paris, FranceLaboratory of Immunology and Immunotherapy of Cancers, EPHE, PSL Research University, 75000 Paris, FranceLaboratory of Immunology and Immunotherapy of Cancers, EPHE, PSL Research University, 75000 Paris, FranceLaboratory of Immunology and Immunotherapy of Cancers, EPHE, PSL Research University, 75000 Paris, FranceLaboratory of Immunology and Immunotherapy of Cancers, EPHE, PSL Research University, 75000 Paris, FranceLaboratory of Immunology and Immunotherapy of Cancers, EPHE, PSL Research University, 75000 Paris, FranceCellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment.https://www.mdpi.com/2072-6694/12/5/1145SASPnitric oxidecancer treatments |
| spellingShingle | Nesrine Mabrouk Silvia Ghione Véronique Laurens Stéphanie Plenchette Ali Bettaieb Catherine Paul Senescence and Cancer: Role of Nitric Oxide (NO) in SASP Cancers SASP nitric oxide cancer treatments |
| title | Senescence and Cancer: Role of Nitric Oxide (NO) in SASP |
| title_full | Senescence and Cancer: Role of Nitric Oxide (NO) in SASP |
| title_fullStr | Senescence and Cancer: Role of Nitric Oxide (NO) in SASP |
| title_full_unstemmed | Senescence and Cancer: Role of Nitric Oxide (NO) in SASP |
| title_short | Senescence and Cancer: Role of Nitric Oxide (NO) in SASP |
| title_sort | senescence and cancer role of nitric oxide no in sasp |
| topic | SASP nitric oxide cancer treatments |
| url | https://www.mdpi.com/2072-6694/12/5/1145 |
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