Herb–Drug Interactions: Worlds Intersect with the Patient at the Center
This review examines three bodies of literature related to herb–drug interactions: case reports, clinical studies, evaluations found in six drug interaction checking resources. The aim of the study is to examine the congruity of resources and to assess the degree to which case reports signal for fur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Medicines |
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| Online Access: | https://www.mdpi.com/2305-6320/8/8/44 |
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| author | Mary Beth Babos Michelle Heinan Linda Redmond Fareeha Moiz Joao Victor Souza-Peres Valerie Samuels Tarun Masimukku David Hamilton Myra Khalid Paul Herscu |
| author_facet | Mary Beth Babos Michelle Heinan Linda Redmond Fareeha Moiz Joao Victor Souza-Peres Valerie Samuels Tarun Masimukku David Hamilton Myra Khalid Paul Herscu |
| author_sort | Mary Beth Babos |
| collection | DOAJ |
| description | This review examines three bodies of literature related to herb–drug interactions: case reports, clinical studies, evaluations found in six drug interaction checking resources. The aim of the study is to examine the congruity of resources and to assess the degree to which case reports signal for further study. A qualitative review of case reports seeks to determine needs and perspectives of case report authors. <b>Methods:</b> Systematic search of Medline identified clinical studies and case reports of interacting herb–drug combinations. Interacting herb–drug pairs were searched in six drug interaction resources. Case reports were analyzed qualitatively for completeness and to identify underlying themes. <b>Results:</b> Ninety-nine case-report documents detailed 107 cases. Sixty-five clinical studies evaluated 93 mechanisms of interaction relevant to herbs reported in case studies, involving 30 different herbal products; 52.7% of these investigations offered evidence supporting reported reactions. Cohen’s kappa found no agreement between any interaction checker and case report corpus. Case reports often lacked full information. Need for further information, attitudes about herbs and herb use, and strategies to reduce risk from interaction were three primary themes in the case report corpus. <b>Conclusions:</b> Reliable herb–drug information is needed, including open and respectful discussion with patients. |
| first_indexed | 2024-03-10T08:36:56Z |
| format | Article |
| id | doaj.art-45fed5c72a804c3d9a542a901d1ace58 |
| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-03-10T08:36:56Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicines |
| spelling | doaj.art-45fed5c72a804c3d9a542a901d1ace582023-11-22T08:37:14ZengMDPI AGMedicines2305-63202021-08-01884410.3390/medicines8080044Herb–Drug Interactions: Worlds Intersect with the Patient at the CenterMary Beth Babos0Michelle Heinan1Linda Redmond2Fareeha Moiz3Joao Victor Souza-Peres4Valerie Samuels5Tarun Masimukku6David Hamilton7Myra Khalid8Paul Herscu9DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN 37752, USASchool of Medical Sciences, Lincoln Memoria University, Harrogate, TN 37752, USAMedical Center Long Term Care, University of Pittsburgh, Pittsburgh, PA 15260, USADeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN 37752, USADeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN 37752, USADeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN 37752, USADeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN 37752, USAOf the Earth Wellness, Charlotte, NC 28204, USADeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN 37752, USAResearch Division, Herscu Laboratory, Amherst, MA 01002, USAThis review examines three bodies of literature related to herb–drug interactions: case reports, clinical studies, evaluations found in six drug interaction checking resources. The aim of the study is to examine the congruity of resources and to assess the degree to which case reports signal for further study. A qualitative review of case reports seeks to determine needs and perspectives of case report authors. <b>Methods:</b> Systematic search of Medline identified clinical studies and case reports of interacting herb–drug combinations. Interacting herb–drug pairs were searched in six drug interaction resources. Case reports were analyzed qualitatively for completeness and to identify underlying themes. <b>Results:</b> Ninety-nine case-report documents detailed 107 cases. Sixty-five clinical studies evaluated 93 mechanisms of interaction relevant to herbs reported in case studies, involving 30 different herbal products; 52.7% of these investigations offered evidence supporting reported reactions. Cohen’s kappa found no agreement between any interaction checker and case report corpus. Case reports often lacked full information. Need for further information, attitudes about herbs and herb use, and strategies to reduce risk from interaction were three primary themes in the case report corpus. <b>Conclusions:</b> Reliable herb–drug information is needed, including open and respectful discussion with patients.https://www.mdpi.com/2305-6320/8/8/44herb drug interactionpharmacovigilancephytovigilancedrug interaction |
| spellingShingle | Mary Beth Babos Michelle Heinan Linda Redmond Fareeha Moiz Joao Victor Souza-Peres Valerie Samuels Tarun Masimukku David Hamilton Myra Khalid Paul Herscu Herb–Drug Interactions: Worlds Intersect with the Patient at the Center Medicines herb drug interaction pharmacovigilance phytovigilance drug interaction |
| title | Herb–Drug Interactions: Worlds Intersect with the Patient at the Center |
| title_full | Herb–Drug Interactions: Worlds Intersect with the Patient at the Center |
| title_fullStr | Herb–Drug Interactions: Worlds Intersect with the Patient at the Center |
| title_full_unstemmed | Herb–Drug Interactions: Worlds Intersect with the Patient at the Center |
| title_short | Herb–Drug Interactions: Worlds Intersect with the Patient at the Center |
| title_sort | herb drug interactions worlds intersect with the patient at the center |
| topic | herb drug interaction pharmacovigilance phytovigilance drug interaction |
| url | https://www.mdpi.com/2305-6320/8/8/44 |
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