Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves
The Pharmacokinetic aspects of flunixin (FL) administered alone and in combination with enrofloxacin (EN), were studied in clinically healthy calves. The experiments were performed on two groups: FL alone {2.2 mg/kg,intramuscular (IM)}, and combination of FL (2.2 mg/kg, IM) and EN {2.5 mg/kg, IM}. P...
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| Format: | Article |
| Language: | English |
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Veterinary World
2011-01-01
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| Series: | Veterinary World |
| Subjects: | |
| Online Access: | http://www.scopemed.org/mnstemps/2/2-1315561016.pdf |
| _version_ | 1818742931523108864 |
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| author | K. Abo-EL-Sooud L. AL-Anati |
| author_facet | K. Abo-EL-Sooud L. AL-Anati |
| author_sort | K. Abo-EL-Sooud |
| collection | DOAJ |
| description | The Pharmacokinetic aspects of flunixin (FL) administered alone and in combination with enrofloxacin (EN), were studied in clinically healthy calves. The experiments were performed on two groups: FL alone {2.2 mg/kg,intramuscular (IM)}, and combination of FL (2.2 mg/kg, IM) and EN {2.5 mg/kg, IM}. Plasma concentrations of FL were determined using High Performance Liquid Chromatography (HPLC) method. Moreover, the effects of FL alone or in combination on liver and kidney functions were also assessed. Flunixin was rapidly absorbed intramuscularly with a half-life of absorption (t ) of 0.094 h and the peak plasma concentration (C ) was 1.27 g/mL was attained after 1/2ab max 0.49 h (T ). Enrofloxacin significantly altered the pharmacokinetics of FL by delaying its absorption and accelerate its max elimination from body. Significant increases (32%) in the area under the curve (AUC) and (37%) in the elimination rate constant (K ) from the central compartment and a significant decrease (27%) in the elimination half-life (t ) of FL el 1/2el were found following coadministration with EN, compared with administration of FL alone. The maximum plasma drug concentration (C ) showed significant increase (28%) following the coadministration of EN with FL as max compared to that following the administration of FL alone. It was concluded that the combination of FL and EN negatively altered the kinetics of FL and exaggerated the adverse effect on hepato-renal function in calves consequently; the concomitant use of FL and EN should be avoided in calves. [Vet. World 2011; 4(10.000): 449-454] |
| first_indexed | 2024-12-18T02:20:21Z |
| format | Article |
| id | doaj.art-45ff672401f0426fa34283e79911e18a |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-18T02:20:21Z |
| publishDate | 2011-01-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-45ff672401f0426fa34283e79911e18a2022-12-21T21:24:14ZengVeterinary WorldVeterinary World0972-89882231-09162011-01-01410.000449454Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calvesK. Abo-EL-SooudL. AL-AnatiThe Pharmacokinetic aspects of flunixin (FL) administered alone and in combination with enrofloxacin (EN), were studied in clinically healthy calves. The experiments were performed on two groups: FL alone {2.2 mg/kg,intramuscular (IM)}, and combination of FL (2.2 mg/kg, IM) and EN {2.5 mg/kg, IM}. Plasma concentrations of FL were determined using High Performance Liquid Chromatography (HPLC) method. Moreover, the effects of FL alone or in combination on liver and kidney functions were also assessed. Flunixin was rapidly absorbed intramuscularly with a half-life of absorption (t ) of 0.094 h and the peak plasma concentration (C ) was 1.27 g/mL was attained after 1/2ab max 0.49 h (T ). Enrofloxacin significantly altered the pharmacokinetics of FL by delaying its absorption and accelerate its max elimination from body. Significant increases (32%) in the area under the curve (AUC) and (37%) in the elimination rate constant (K ) from the central compartment and a significant decrease (27%) in the elimination half-life (t ) of FL el 1/2el were found following coadministration with EN, compared with administration of FL alone. The maximum plasma drug concentration (C ) showed significant increase (28%) following the coadministration of EN with FL as max compared to that following the administration of FL alone. It was concluded that the combination of FL and EN negatively altered the kinetics of FL and exaggerated the adverse effect on hepato-renal function in calves consequently; the concomitant use of FL and EN should be avoided in calves. [Vet. World 2011; 4(10.000): 449-454]http://www.scopemed.org/mnstemps/2/2-1315561016.pdfPharmacokineticsFlunixinInteractionEnrofloxacinCalves |
| spellingShingle | K. Abo-EL-Sooud L. AL-Anati Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves Veterinary World Pharmacokinetics Flunixin Interaction Enrofloxacin Calves |
| title | Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves |
| title_full | Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves |
| title_fullStr | Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves |
| title_full_unstemmed | Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves |
| title_short | Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves |
| title_sort | pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves |
| topic | Pharmacokinetics Flunixin Interaction Enrofloxacin Calves |
| url | http://www.scopemed.org/mnstemps/2/2-1315561016.pdf |
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