FLRTing Neurons in Cortical Migration During Cerebral Cortex Development
During development, two coordinated events shape the morphology of the mammalian cerebral cortex, leading to the cortex’s columnar and layered structure: the proliferation of neuronal progenitors and cortical migration. Pyramidal neurons originating from germinal zones migrate along radial glial fib...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.578506/full |
| _version_ | 1811323932856287232 |
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| author | Claudia Peregrina Claudia Peregrina Claudia Peregrina Daniel del Toro Daniel del Toro Daniel del Toro |
| author_facet | Claudia Peregrina Claudia Peregrina Claudia Peregrina Daniel del Toro Daniel del Toro Daniel del Toro |
| author_sort | Claudia Peregrina |
| collection | DOAJ |
| description | During development, two coordinated events shape the morphology of the mammalian cerebral cortex, leading to the cortex’s columnar and layered structure: the proliferation of neuronal progenitors and cortical migration. Pyramidal neurons originating from germinal zones migrate along radial glial fibers to their final position in the cortical plate by both radial migration and tangential dispersion. These processes rely on the delicate balance of intercellular adhesive and repulsive signaling that takes place between neurons interacting with different substrates and guidance cues. Here, we focus on the function of the cell adhesion molecules fibronectin leucine-rich repeat transmembrane proteins (FLRTs) in regulating both the radial migration of neurons, as well as their tangential spread, and the impact these processes have on cortex morphogenesis. In combining structural and functional analysis, recent studies have begun to reveal how FLRT-mediated responses are precisely tuned – from forming different protein complexes to modulate either cell adhesion or repulsion in neurons. These approaches provide a deeper understanding of the context-dependent interactions of FLRTs with multiple receptors involved in axon guidance and synapse formation that contribute to finely regulated neuronal migration. |
| first_indexed | 2024-04-13T14:04:11Z |
| format | Article |
| id | doaj.art-4600a2d7413d4d938884cd04895c457b |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T14:04:11Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-4600a2d7413d4d938884cd04895c457b2022-12-22T02:43:57ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-09-01810.3389/fcell.2020.578506578506FLRTing Neurons in Cortical Migration During Cerebral Cortex DevelopmentClaudia Peregrina0Claudia Peregrina1Claudia Peregrina2Daniel del Toro3Daniel del Toro4Daniel del Toro5Department of Biological Sciences, Faculty of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, SpainDepartment of Biological Sciences, Faculty of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, SpainDuring development, two coordinated events shape the morphology of the mammalian cerebral cortex, leading to the cortex’s columnar and layered structure: the proliferation of neuronal progenitors and cortical migration. Pyramidal neurons originating from germinal zones migrate along radial glial fibers to their final position in the cortical plate by both radial migration and tangential dispersion. These processes rely on the delicate balance of intercellular adhesive and repulsive signaling that takes place between neurons interacting with different substrates and guidance cues. Here, we focus on the function of the cell adhesion molecules fibronectin leucine-rich repeat transmembrane proteins (FLRTs) in regulating both the radial migration of neurons, as well as their tangential spread, and the impact these processes have on cortex morphogenesis. In combining structural and functional analysis, recent studies have begun to reveal how FLRT-mediated responses are precisely tuned – from forming different protein complexes to modulate either cell adhesion or repulsion in neurons. These approaches provide a deeper understanding of the context-dependent interactions of FLRTs with multiple receptors involved in axon guidance and synapse formation that contribute to finely regulated neuronal migration.https://www.frontiersin.org/article/10.3389/fcell.2020.578506/fullFLRTLatrophilinadhesionrepulsionneuronal migrationTeneurin |
| spellingShingle | Claudia Peregrina Claudia Peregrina Claudia Peregrina Daniel del Toro Daniel del Toro Daniel del Toro FLRTing Neurons in Cortical Migration During Cerebral Cortex Development Frontiers in Cell and Developmental Biology FLRT Latrophilin adhesion repulsion neuronal migration Teneurin |
| title | FLRTing Neurons in Cortical Migration During Cerebral Cortex Development |
| title_full | FLRTing Neurons in Cortical Migration During Cerebral Cortex Development |
| title_fullStr | FLRTing Neurons in Cortical Migration During Cerebral Cortex Development |
| title_full_unstemmed | FLRTing Neurons in Cortical Migration During Cerebral Cortex Development |
| title_short | FLRTing Neurons in Cortical Migration During Cerebral Cortex Development |
| title_sort | flrting neurons in cortical migration during cerebral cortex development |
| topic | FLRT Latrophilin adhesion repulsion neuronal migration Teneurin |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.578506/full |
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