Brain Resting-State Network Alterations Associated With Crohn's Disease
Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00048/full |
| _version_ | 1818524035424714752 |
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| author | Jennifer Kornelsen Jennifer Kornelsen Alyssia Wilson Jennifer S. Labus Kelcie Witges Emeran A. Mayer Charles N. Bernstein Charles N. Bernstein |
| author_facet | Jennifer Kornelsen Jennifer Kornelsen Alyssia Wilson Jennifer S. Labus Kelcie Witges Emeran A. Mayer Charles N. Bernstein Charles N. Bernstein |
| author_sort | Jennifer Kornelsen |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Region of interest (ROI) analyses were run to assess FC for resting-state network nodes. Independent component analysis (ICA) identified whole brain differences in FC associated with resting-state networks. Though no structural differences were found, ROI analyses showed increased FC between the frontoparietal (FP) network and salience network (SN), and decreased FC between nodes of the default mode network (DMN). ICA results revealed changes involving cerebellar (CER), visual (VIS), and SN components. Differences in FC associated with sex were observed for both ROI analysis and ICA. Taken together, these changes are consistent with an influence of CD on the brain and serve to direct future research hypotheses. |
| first_indexed | 2024-12-11T05:52:12Z |
| format | Article |
| id | doaj.art-4601ba9a07674d9ba868db046e9b8992 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T05:52:12Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4601ba9a07674d9ba868db046e9b89922022-12-22T01:18:47ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-02-011110.3389/fneur.2020.00048510545Brain Resting-State Network Alterations Associated With Crohn's DiseaseJennifer Kornelsen0Jennifer Kornelsen1Alyssia Wilson2Jennifer S. Labus3Kelcie Witges4Emeran A. Mayer5Charles N. Bernstein6Charles N. Bernstein7Department of Radiology, University of Manitoba, Winnipeg, MB, CanadaIBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, CanadaDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, CanadaG. Oppenheimer Family Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine at UCLA, Los Angeles, CA, United StatesIBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, CanadaG. Oppenheimer Family Center for Neurobiology of Stress and Resilience, David Geffen School of Medicine at UCLA, Los Angeles, CA, United StatesIBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, CanadaDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, CanadaInflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Region of interest (ROI) analyses were run to assess FC for resting-state network nodes. Independent component analysis (ICA) identified whole brain differences in FC associated with resting-state networks. Though no structural differences were found, ROI analyses showed increased FC between the frontoparietal (FP) network and salience network (SN), and decreased FC between nodes of the default mode network (DMN). ICA results revealed changes involving cerebellar (CER), visual (VIS), and SN components. Differences in FC associated with sex were observed for both ROI analysis and ICA. Taken together, these changes are consistent with an influence of CD on the brain and serve to direct future research hypotheses.https://www.frontiersin.org/article/10.3389/fneur.2020.00048/fullCrohn's disease (CD)resting-state networks (RSNs)functional connectivity (FC)functional magnetic resonance imaging (fMRI)inflammatory bowel disease (IBD) |
| spellingShingle | Jennifer Kornelsen Jennifer Kornelsen Alyssia Wilson Jennifer S. Labus Kelcie Witges Emeran A. Mayer Charles N. Bernstein Charles N. Bernstein Brain Resting-State Network Alterations Associated With Crohn's Disease Frontiers in Neurology Crohn's disease (CD) resting-state networks (RSNs) functional connectivity (FC) functional magnetic resonance imaging (fMRI) inflammatory bowel disease (IBD) |
| title | Brain Resting-State Network Alterations Associated With Crohn's Disease |
| title_full | Brain Resting-State Network Alterations Associated With Crohn's Disease |
| title_fullStr | Brain Resting-State Network Alterations Associated With Crohn's Disease |
| title_full_unstemmed | Brain Resting-State Network Alterations Associated With Crohn's Disease |
| title_short | Brain Resting-State Network Alterations Associated With Crohn's Disease |
| title_sort | brain resting state network alterations associated with crohn s disease |
| topic | Crohn's disease (CD) resting-state networks (RSNs) functional connectivity (FC) functional magnetic resonance imaging (fMRI) inflammatory bowel disease (IBD) |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00048/full |
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