Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly
An optimal immune response requires the appropriate interaction between the innate and the adaptive arms of the immune system as well as a proper balance of activation and regulation. After decades of life, the aging immune system is continuously exposed to immune stressors and inflammatory assaults...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Aging |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2022.840827/full |
| _version_ | 1828847819606196224 |
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| author | Carey Shive Carey Shive Pushpa Pandiyan |
| author_facet | Carey Shive Carey Shive Pushpa Pandiyan |
| author_sort | Carey Shive |
| collection | DOAJ |
| description | An optimal immune response requires the appropriate interaction between the innate and the adaptive arms of the immune system as well as a proper balance of activation and regulation. After decades of life, the aging immune system is continuously exposed to immune stressors and inflammatory assaults that lead to immune senescence. In this review, we will discuss inflammaging in the elderly, specifically concentrating on IL-6 and IL-1b in the context of T lymphocytes, and how inflammation is related to mortality and morbidities, specifically cardiovascular disease and cancer. Although a number of studies suggests that the anti-inflammatory cytokine TGF-b is elevated in the elderly, heightened inflammation persists. Thus, the regulation of the immune response and the ability to return the immune system to homeostasis is also important. Therefore, we will discuss cellular alterations in aging, concentrating on senescent T cells and CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) in aging |
| first_indexed | 2024-12-12T22:17:53Z |
| format | Article |
| id | doaj.art-4603f80006d4461fbc99a3b75ad25fac |
| institution | Directory Open Access Journal |
| issn | 2673-6217 |
| language | English |
| last_indexed | 2024-12-12T22:17:53Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj.art-4603f80006d4461fbc99a3b75ad25fac2022-12-22T00:10:01ZengFrontiers Media S.A.Frontiers in Aging2673-62172022-04-01310.3389/fragi.2022.840827840827Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the ElderlyCarey Shive0Carey Shive1Pushpa Pandiyan2Louis Stokes Cleveland VA Medical Center, United States Department of Veterans Affairs, Cleveland, OH, United StatesCase Western Reserve University, Cleveland, OH, United StatesCase Western Reserve University, Cleveland, OH, United StatesAn optimal immune response requires the appropriate interaction between the innate and the adaptive arms of the immune system as well as a proper balance of activation and regulation. After decades of life, the aging immune system is continuously exposed to immune stressors and inflammatory assaults that lead to immune senescence. In this review, we will discuss inflammaging in the elderly, specifically concentrating on IL-6 and IL-1b in the context of T lymphocytes, and how inflammation is related to mortality and morbidities, specifically cardiovascular disease and cancer. Although a number of studies suggests that the anti-inflammatory cytokine TGF-b is elevated in the elderly, heightened inflammation persists. Thus, the regulation of the immune response and the ability to return the immune system to homeostasis is also important. Therefore, we will discuss cellular alterations in aging, concentrating on senescent T cells and CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) in aginghttps://www.frontiersin.org/articles/10.3389/fragi.2022.840827/fullinflammagingelderlyimmune senescencedysregulated tregst cell senescenceinflammation |
| spellingShingle | Carey Shive Carey Shive Pushpa Pandiyan Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly Frontiers in Aging inflammaging elderly immune senescence dysregulated tregs t cell senescence inflammation |
| title | Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly |
| title_full | Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly |
| title_fullStr | Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly |
| title_full_unstemmed | Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly |
| title_short | Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly |
| title_sort | inflammation immune senescence and dysregulated immune regulation in the elderly |
| topic | inflammaging elderly immune senescence dysregulated tregs t cell senescence inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2022.840827/full |
| work_keys_str_mv | AT careyshive inflammationimmunesenescenceanddysregulatedimmuneregulationintheelderly AT careyshive inflammationimmunesenescenceanddysregulatedimmuneregulationintheelderly AT pushpapandiyan inflammationimmunesenescenceanddysregulatedimmuneregulationintheelderly |