The Protective Effect of <i>Gynura procumbens</i> Adventitious Root against Lead Acetate Toxicity in Mice
Lead induced oxidative stress contributes to increase the productivity of reactive oxygen species (ROS) and to disrupt the antioxidant balance. Gynura procumbens adventitious root (GPAR) methanol extract contains abundant phenolic and flavonoids compounds as antioxidants and can be used as tradition...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2022-05-01
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| Series: | Journal of Tropical Biodiversity and Biotechnology |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/jtbb/article/view/69453 |
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| author | Sugiharto Sugiharto Dwi Winarni Ufairanisa Islamatasya Abdul Hakim Muhsyi Ahimsa Buena Merpati Yosephine Sri Wulan Manuhara |
| author_facet | Sugiharto Sugiharto Dwi Winarni Ufairanisa Islamatasya Abdul Hakim Muhsyi Ahimsa Buena Merpati Yosephine Sri Wulan Manuhara |
| author_sort | Sugiharto Sugiharto |
| collection | DOAJ |
| description | Lead induced oxidative stress contributes to increase the productivity of reactive oxygen species (ROS) and to disrupt the antioxidant balance. Gynura procumbens adventitious root (GPAR) methanol extract contains abundant phenolic and flavonoids compounds as antioxidants and can be used as traditional medicinal plants. The objective of this study is to evaluate the protective effect of GPAR against lead acetate toxicity in mice to haematological parameter, histological of hepatic cells, and activities of antioxidant enzymes. The data obtained from five groups of treatment: P1 (control), P2 (Pb acetate-100 mg/L), P3 (GPAR-100 mg/L + Pb acetate-100 mg/L), P4 (GPAR-200 mg/L + Pb acetate-100 mg/L), P5 (GPAR-300 mg/L + Pb acetate-100 mg/L). The results indicated that administration of methanol extract of GPAR can prevent the decreasing of haematological parameter, maintain the percentage of normal hepatic cells, activities of superoxide dismutase (SOD), and catalase (CAT) due to lead acetate treatment. The effective dose of GPAR extract was 300 mg/L. This study provides that methanol extract of G. procumbens adventitious root exerts protective effects against lead acetate toxicity in mice. |
| first_indexed | 2024-12-11T21:17:51Z |
| format | Article |
| id | doaj.art-4604fc8355ab4999bc7fda970b08bb0e |
| institution | Directory Open Access Journal |
| issn | 2540-9573 2540-9581 |
| language | English |
| last_indexed | 2024-12-11T21:17:51Z |
| publishDate | 2022-05-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Journal of Tropical Biodiversity and Biotechnology |
| spelling | doaj.art-4604fc8355ab4999bc7fda970b08bb0e2022-12-22T00:50:32ZengUniversitas Gadjah MadaJournal of Tropical Biodiversity and Biotechnology2540-95732540-95812022-05-017210.22146/jtbb.6945331769The Protective Effect of <i>Gynura procumbens</i> Adventitious Root against Lead Acetate Toxicity in MiceSugiharto Sugiharto0Dwi Winarni1Ufairanisa Islamatasya2Abdul Hakim Muhsyi3Ahimsa Buena Merpati4Yosephine Sri Wulan Manuhara5Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Mulyorejo, Surabaya, East Java 60115; Biotechnology of Tropical Medicinal Plants Research Group, Faculty of Science and Technology, Universitas Airlangga, Mulyorejo, Surabaya, East Java 60115Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Mulyorejo, Surabaya, East Java 60115Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Mulyorejo, Surabaya, East Java 60115Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Mulyorejo, Surabaya, East Java 60115Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Mulyorejo, Surabaya, East Java 60115Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Mulyorejo, Surabaya, East Java 60115; Biotechnology of Tropical Medicinal Plants Research Group, Faculty of Science and Technology, Universitas Airlangga, Mulyorejo, Surabaya, East Java 60115Lead induced oxidative stress contributes to increase the productivity of reactive oxygen species (ROS) and to disrupt the antioxidant balance. Gynura procumbens adventitious root (GPAR) methanol extract contains abundant phenolic and flavonoids compounds as antioxidants and can be used as traditional medicinal plants. The objective of this study is to evaluate the protective effect of GPAR against lead acetate toxicity in mice to haematological parameter, histological of hepatic cells, and activities of antioxidant enzymes. The data obtained from five groups of treatment: P1 (control), P2 (Pb acetate-100 mg/L), P3 (GPAR-100 mg/L + Pb acetate-100 mg/L), P4 (GPAR-200 mg/L + Pb acetate-100 mg/L), P5 (GPAR-300 mg/L + Pb acetate-100 mg/L). The results indicated that administration of methanol extract of GPAR can prevent the decreasing of haematological parameter, maintain the percentage of normal hepatic cells, activities of superoxide dismutase (SOD), and catalase (CAT) due to lead acetate treatment. The effective dose of GPAR extract was 300 mg/L. This study provides that methanol extract of G. procumbens adventitious root exerts protective effects against lead acetate toxicity in mice.https://jurnal.ugm.ac.id/jtbb/article/view/69453adventitious root of gynura procumbensantioxidant enzymeshepatic cellsleadhematological profile |
| spellingShingle | Sugiharto Sugiharto Dwi Winarni Ufairanisa Islamatasya Abdul Hakim Muhsyi Ahimsa Buena Merpati Yosephine Sri Wulan Manuhara The Protective Effect of <i>Gynura procumbens</i> Adventitious Root against Lead Acetate Toxicity in Mice Journal of Tropical Biodiversity and Biotechnology adventitious root of gynura procumbens antioxidant enzymes hepatic cells lead hematological profile |
| title | The Protective Effect of <i>Gynura procumbens</i> Adventitious Root against Lead Acetate Toxicity in Mice |
| title_full | The Protective Effect of <i>Gynura procumbens</i> Adventitious Root against Lead Acetate Toxicity in Mice |
| title_fullStr | The Protective Effect of <i>Gynura procumbens</i> Adventitious Root against Lead Acetate Toxicity in Mice |
| title_full_unstemmed | The Protective Effect of <i>Gynura procumbens</i> Adventitious Root against Lead Acetate Toxicity in Mice |
| title_short | The Protective Effect of <i>Gynura procumbens</i> Adventitious Root against Lead Acetate Toxicity in Mice |
| title_sort | protective effect of i gynura procumbens i adventitious root against lead acetate toxicity in mice |
| topic | adventitious root of gynura procumbens antioxidant enzymes hepatic cells lead hematological profile |
| url | https://jurnal.ugm.ac.id/jtbb/article/view/69453 |
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