CLINICAL IMMUNOLOGIC GROUNDS FOR LOCAL INTERFERON USE IN ACUTE VIRAL INFECTION TREATMENT
<em>Broad spectrum of antiviral activity of interferons lays grounds to its use in complex therapy of acute viral infections. It has been shown that antiviral and antibacterial interferon activity reveals itself while used both systematically and locally. Clinical efficacy of locally applied v...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2011-01-01
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| Series: | Вопросы современной педиатрии |
| Online Access: | http://vsp.spr-journal.ru:80/jour/article/view/678 |
| _version_ | 1827844099477078016 |
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| author | I.N. Zakharova V.V. Malinovskaya N.A. Korovina Kh.I. Kurbanova N.S. Glukhareva N.V. Koroid |
| author_facet | I.N. Zakharova V.V. Malinovskaya N.A. Korovina Kh.I. Kurbanova N.S. Glukhareva N.V. Koroid |
| author_sort | I.N. Zakharova |
| collection | DOAJ |
| description | <em>Broad spectrum of antiviral activity of interferons lays grounds to its use in complex therapy of acute viral infections. It has been shown that antiviral and antibacterial interferon activity reveals itself while used both systematically and locally. Clinical efficacy of locally applied viferon is accompanied by nasal mucosa cytokine status changes, as has been shown in nasal swabs. There has been shown dependency of local immune response on the age, severity of the disease, clinical forms of respiratory syndrome, bacterial complications, if present, intensity and characteristics of viral contamination against the background of viferon treatment.</em><br /> <strong><em>Key words: acute respiratory viral disease, interferon, cell immunity, humoral immunity, interferon status, cytokine status, recombinant </em></strong><strong>α<em>-interferon, immunocorrection.</em></strong><br /> <em><span style="text-decoration: underline;">(<em><span><em><em><em>Voprosy sovremennoi pediatrii — </em></em></em></span></em></span></em><em><span style="text-decoration: underline;">Current Pediatrics. — 2011; 10 (5): 117–123.)</span></em> |
| first_indexed | 2024-03-12T08:36:39Z |
| format | Article |
| id | doaj.art-4605e15d25a74f55a87ba3c5a8acd70b |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T08:36:39Z |
| publishDate | 2011-01-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-4605e15d25a74f55a87ba3c5a8acd70b2023-09-02T17:13:30Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352011-01-01105117123678CLINICAL IMMUNOLOGIC GROUNDS FOR LOCAL INTERFERON USE IN ACUTE VIRAL INFECTION TREATMENTI.N. Zakharova0V.V. Malinovskaya1N.A. Korovina2Kh.I. Kurbanova3N.S. Glukhareva4N.V. Koroid5Russian Medical Academy of Postgraduate Studies Roszdrav, MoscowN.F. Gamalei SRC of Epidemiology and Microbiology RAMS, MoscowRussian Medical Academy of Postgraduate Studies Roszdrav, MoscowRussian Medical Academy of Postgraduate Studies Roszdrav, MoscowTushino City Pediatric Hospital, MoscowTushino City Pediatric Hospital, Moscow<em>Broad spectrum of antiviral activity of interferons lays grounds to its use in complex therapy of acute viral infections. It has been shown that antiviral and antibacterial interferon activity reveals itself while used both systematically and locally. Clinical efficacy of locally applied viferon is accompanied by nasal mucosa cytokine status changes, as has been shown in nasal swabs. There has been shown dependency of local immune response on the age, severity of the disease, clinical forms of respiratory syndrome, bacterial complications, if present, intensity and characteristics of viral contamination against the background of viferon treatment.</em><br /> <strong><em>Key words: acute respiratory viral disease, interferon, cell immunity, humoral immunity, interferon status, cytokine status, recombinant </em></strong><strong>α<em>-interferon, immunocorrection.</em></strong><br /> <em><span style="text-decoration: underline;">(<em><span><em><em><em>Voprosy sovremennoi pediatrii — </em></em></em></span></em></span></em><em><span style="text-decoration: underline;">Current Pediatrics. — 2011; 10 (5): 117–123.)</span></em>http://vsp.spr-journal.ru:80/jour/article/view/678 |
| spellingShingle | I.N. Zakharova V.V. Malinovskaya N.A. Korovina Kh.I. Kurbanova N.S. Glukhareva N.V. Koroid CLINICAL IMMUNOLOGIC GROUNDS FOR LOCAL INTERFERON USE IN ACUTE VIRAL INFECTION TREATMENT Вопросы современной педиатрии |
| title | CLINICAL IMMUNOLOGIC GROUNDS FOR LOCAL INTERFERON USE IN ACUTE VIRAL INFECTION TREATMENT |
| title_full | CLINICAL IMMUNOLOGIC GROUNDS FOR LOCAL INTERFERON USE IN ACUTE VIRAL INFECTION TREATMENT |
| title_fullStr | CLINICAL IMMUNOLOGIC GROUNDS FOR LOCAL INTERFERON USE IN ACUTE VIRAL INFECTION TREATMENT |
| title_full_unstemmed | CLINICAL IMMUNOLOGIC GROUNDS FOR LOCAL INTERFERON USE IN ACUTE VIRAL INFECTION TREATMENT |
| title_short | CLINICAL IMMUNOLOGIC GROUNDS FOR LOCAL INTERFERON USE IN ACUTE VIRAL INFECTION TREATMENT |
| title_sort | clinical immunologic grounds for local interferon use in acute viral infection treatment |
| url | http://vsp.spr-journal.ru:80/jour/article/view/678 |
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