Enolase From Aspergillus fumigatus Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen

Enolase From Aspergillus fumigatus Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen

The opportunistic fungal pathogen Aspergillus fumigatus can cause severe infections, particularly in immunocompromised individuals. Upon infection, A. fumigatus faces the powerful and directly acting immune defense of the human host. The mechanisms on how A. fumigatus evades innate immune attack and...

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Bibliographic Details
Main Authors: Prasad Dasari, Naile Koleci, Iordana A. Shopova, Dirk Wartenberg, Niklas Beyersdorf, Stefanie Dietrich, Alfredo Sahagún-Ruiz, Marc Thilo Figge, Christine Skerka, Axel A. Brakhage, Peter F. Zipfel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
complement factor H
moonlighting
immune evasion
plasminogen
blocking phagocytosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02573/full

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