Lectin‐Like Oxidized Low‐Density Lipoprotein Receptor 1 Inhibition in Type 2 Diabetes: Phase 1 Results
Background Blockade of the lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) is a potentially attractive mechanism for lowering inflammatory and lipid risk in patients with atherosclerosis. This study aims to assess the safety, tolerability, and target engagement of MEDI6570, a high‐af...
Main Authors: | Andrea L. Vavere, Marvin Sinsakul, Emily L. Ongstad, Ye Yang, Vijayalakshmi Varma, Christopher Jones, Joanne Goodman, Vincent F. S. Dubois, Angelica L. Quartino, Sotirios K. Karathanasis, Liron Abuhatzira, Anna Collén, Charalambos Antoniades, Michael J. Koren, Ruchi Gupta, Richard T. George |
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Format: | Article |
Language: | English |
Published: |
Wiley
2023-02-01
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Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
Subjects: | |
Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.027540 |
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