Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis
The early diagnosis of biliary atresia (BA) in cholestatic infants is critical to the success of the treatment. Intraoperative cholangiography (IOC), an invasive imaging technique, is the current strategy for the diagnosis of BA. Ultrasonography has advanced over recent years and emerging techniques...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/9/11/1676 |
| _version_ | 1797468701474160640 |
|---|---|
| author | Simon Takadiyi Gunda Nonhlanhla Chambara Xiangyan Fiona Chen Marco Yiu Chung Pang Michael Tin-cheung Ying |
| author_facet | Simon Takadiyi Gunda Nonhlanhla Chambara Xiangyan Fiona Chen Marco Yiu Chung Pang Michael Tin-cheung Ying |
| author_sort | Simon Takadiyi Gunda |
| collection | DOAJ |
| description | The early diagnosis of biliary atresia (BA) in cholestatic infants is critical to the success of the treatment. Intraoperative cholangiography (IOC), an invasive imaging technique, is the current strategy for the diagnosis of BA. Ultrasonography has advanced over recent years and emerging techniques such as shear wave elastography (SWE) have the potential to improve BA diagnosis. This review sought to evaluate the diagnostic efficacy of advanced ultrasonography techniques in the diagnosis of BA. Six databases (CINAHL, Medline, PubMed, Google Scholar, Web of Science (core collection), and Embase) were searched for studies assessing the diagnostic performance of advanced ultrasonography techniques in differentiating BA from non-BA causes of infantile cholestasis. The meta-analysis was performed using Meta-DiSc 1.4 and Comprehensive Meta-analysis v3 software. Quality Assessment of Diagnostic Accuracy Studies tool version 2 (QUADAS-2) assessed the risk of bias. Fifteen studies consisting of 2185 patients (BA = 1105; non-BA = 1080) met the inclusion criteria. SWE was the only advanced ultrasonography technique reported and had a good pooled diagnostic performance (sensitivity = 83%; specificity = 77%; AUC = 0.896). Liver stiffness indicators were significantly higher in BA compared to non-BA patients (<i>p</i> < 0.000). SWE could be a useful tool in differentiating BA from non-BA causes of infantile cholestasis. Future studies to assess the utility of other advanced ultrasonography techniques are recommended. |
| first_indexed | 2024-03-09T19:10:13Z |
| format | Article |
| id | doaj.art-46097ccf24e3426d95d001a55731aca0 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T19:10:13Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-46097ccf24e3426d95d001a55731aca02023-11-24T04:12:02ZengMDPI AGChildren2227-90672022-10-01911167610.3390/children9111676Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-AnalysisSimon Takadiyi Gunda0Nonhlanhla Chambara1Xiangyan Fiona Chen2Marco Yiu Chung Pang3Michael Tin-cheung Ying4Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, ChinaDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, ChinaDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, ChinaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, ChinaDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, ChinaThe early diagnosis of biliary atresia (BA) in cholestatic infants is critical to the success of the treatment. Intraoperative cholangiography (IOC), an invasive imaging technique, is the current strategy for the diagnosis of BA. Ultrasonography has advanced over recent years and emerging techniques such as shear wave elastography (SWE) have the potential to improve BA diagnosis. This review sought to evaluate the diagnostic efficacy of advanced ultrasonography techniques in the diagnosis of BA. Six databases (CINAHL, Medline, PubMed, Google Scholar, Web of Science (core collection), and Embase) were searched for studies assessing the diagnostic performance of advanced ultrasonography techniques in differentiating BA from non-BA causes of infantile cholestasis. The meta-analysis was performed using Meta-DiSc 1.4 and Comprehensive Meta-analysis v3 software. Quality Assessment of Diagnostic Accuracy Studies tool version 2 (QUADAS-2) assessed the risk of bias. Fifteen studies consisting of 2185 patients (BA = 1105; non-BA = 1080) met the inclusion criteria. SWE was the only advanced ultrasonography technique reported and had a good pooled diagnostic performance (sensitivity = 83%; specificity = 77%; AUC = 0.896). Liver stiffness indicators were significantly higher in BA compared to non-BA patients (<i>p</i> < 0.000). SWE could be a useful tool in differentiating BA from non-BA causes of infantile cholestasis. Future studies to assess the utility of other advanced ultrasonography techniques are recommended.https://www.mdpi.com/2227-9067/9/11/1676biliary atresiaultrasonographydiagnostic accuracyintraoperative cholangiography (IOC)diagnostic performanceelastography |
| spellingShingle | Simon Takadiyi Gunda Nonhlanhla Chambara Xiangyan Fiona Chen Marco Yiu Chung Pang Michael Tin-cheung Ying Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis Children biliary atresia ultrasonography diagnostic accuracy intraoperative cholangiography (IOC) diagnostic performance elastography |
| title | Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis |
| title_full | Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis |
| title_fullStr | Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis |
| title_short | Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis |
| title_sort | diagnostic efficacy of advanced ultrasonography imaging techniques in infants with biliary atresia ba a systematic review and meta analysis |
| topic | biliary atresia ultrasonography diagnostic accuracy intraoperative cholangiography (IOC) diagnostic performance elastography |
| url | https://www.mdpi.com/2227-9067/9/11/1676 |
| work_keys_str_mv | AT simontakadiyigunda diagnosticefficacyofadvancedultrasonographyimagingtechniquesininfantswithbiliaryatresiabaasystematicreviewandmetaanalysis AT nonhlanhlachambara diagnosticefficacyofadvancedultrasonographyimagingtechniquesininfantswithbiliaryatresiabaasystematicreviewandmetaanalysis AT xiangyanfionachen diagnosticefficacyofadvancedultrasonographyimagingtechniquesininfantswithbiliaryatresiabaasystematicreviewandmetaanalysis AT marcoyiuchungpang diagnosticefficacyofadvancedultrasonographyimagingtechniquesininfantswithbiliaryatresiabaasystematicreviewandmetaanalysis AT michaeltincheungying diagnosticefficacyofadvancedultrasonographyimagingtechniquesininfantswithbiliaryatresiabaasystematicreviewandmetaanalysis |