History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer
Objective: To evaluate the utility of infantile BCG vaccination history in predicting stage and grade of tumours in non-muscle invasive bladder cancer (NMIBC). Materials and methods: We retrospectively analyzed data from patients from a single center who were diagnosed with new NMIBC and underwent...
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| Format: | Article |
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PAGEPress Publications
2023-05-01
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| Series: | Archivio Italiano di Urologia e Andrologia |
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| Online Access: | https://pagepressjournals.org/index.php/aiua/article/view/11380 |
| _version_ | 1797814546979618816 |
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| author | Anastasia MacDonald Vahid Mehrnoush Asmaa Ismail Livio Di Matteo Ahmed Zakaria Waleed Shabana Ashraf Shaban Mohammed Bassuony Hazem Elmansy Walid Shahrour Owen Prowse Ahmed Kotb |
| author_facet | Anastasia MacDonald Vahid Mehrnoush Asmaa Ismail Livio Di Matteo Ahmed Zakaria Waleed Shabana Ashraf Shaban Mohammed Bassuony Hazem Elmansy Walid Shahrour Owen Prowse Ahmed Kotb |
| author_sort | Anastasia MacDonald |
| collection | DOAJ |
| description |
Objective: To evaluate the utility of infantile BCG vaccination history in predicting stage and grade of tumours in non-muscle invasive bladder cancer (NMIBC). Materials and methods: We retrospectively analyzed data from patients from a single center who were diagnosed with new NMIBC and underwent transurethral resection of bladder tumour (TURBT) between 2017 and 2022. We assessed BCG immunization status with various demographics and comorbidities, as well as tumour recurrence, progression, stage, and grade. Results: A total of 188 patients met the inclusion criteria for our study. The mean age of patients at the time of diagnosis was significantly lower in those that had been immunized with BCG (71 ± 9) than those who had not (77 ± 10) (p < 0.0001). History of BCG immunization did not correlate with sex, history of diabetes mellitus (DM), prior history of intravesical BCG treatment, and tumour recurrence, progression, stage, and grade. Conclusions: History of infantile BCG vaccination did not correlate with the depth of invasion and/or the grade in patients with non-muscle invasive bladder cancer. Patients that received infantile BCG vaccination were significantly younger at the time of diagnosis of NMIBC.
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| first_indexed | 2024-03-13T08:09:15Z |
| format | Article |
| id | doaj.art-460b108db2ea4c33a97dbcb9d1573d85 |
| institution | Directory Open Access Journal |
| issn | 1124-3562 2282-4197 |
| language | English |
| last_indexed | 2024-03-13T08:09:15Z |
| publishDate | 2023-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Archivio Italiano di Urologia e Andrologia |
| spelling | doaj.art-460b108db2ea4c33a97dbcb9d1573d852023-05-31T22:49:43ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972023-05-0110.4081/aiua.2023.11380History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancerAnastasia MacDonald0Vahid Mehrnoush1Asmaa Ismail2Livio Di Matteo3Ahmed Zakaria4Waleed Shabana5Ashraf Shaban6Mohammed Bassuony7Hazem Elmansy8Walid Shahrour9Owen Prowse10Ahmed Kotb11Northern Ontario School of Medicine, Thunder Bay, ONNorthern Ontario School of Medicine, Thunder Bay, ONNorthern Ontario School of Medicine, Thunder Bay, ONDepartment of Economics, Lakehead University, Thunder Bay, ONNorthern Ontario School of Medicine, Thunder Bay, ONNorthern Ontario School of Medicine, Thunder Bay, ONNorthern Ontario School of Medicine, Thunder Bay, ONNorthern Ontario School of Medicine, Thunder Bay, ON Northern Ontario School of Medicine, Thunder Bay, ONNorthern Ontario School of Medicine, Thunder Bay, ONNorthern Ontario School of Medicine, Thunder Bay, ONNorthern Ontario School of Medicine, Thunder Bay, ON Objective: To evaluate the utility of infantile BCG vaccination history in predicting stage and grade of tumours in non-muscle invasive bladder cancer (NMIBC). Materials and methods: We retrospectively analyzed data from patients from a single center who were diagnosed with new NMIBC and underwent transurethral resection of bladder tumour (TURBT) between 2017 and 2022. We assessed BCG immunization status with various demographics and comorbidities, as well as tumour recurrence, progression, stage, and grade. Results: A total of 188 patients met the inclusion criteria for our study. The mean age of patients at the time of diagnosis was significantly lower in those that had been immunized with BCG (71 ± 9) than those who had not (77 ± 10) (p < 0.0001). History of BCG immunization did not correlate with sex, history of diabetes mellitus (DM), prior history of intravesical BCG treatment, and tumour recurrence, progression, stage, and grade. Conclusions: History of infantile BCG vaccination did not correlate with the depth of invasion and/or the grade in patients with non-muscle invasive bladder cancer. Patients that received infantile BCG vaccination were significantly younger at the time of diagnosis of NMIBC. https://pagepressjournals.org/index.php/aiua/article/view/11380BCGNon-muscle invasive bladder cancer (NMIBT)Bladder cancer |
| spellingShingle | Anastasia MacDonald Vahid Mehrnoush Asmaa Ismail Livio Di Matteo Ahmed Zakaria Waleed Shabana Ashraf Shaban Mohammed Bassuony Hazem Elmansy Walid Shahrour Owen Prowse Ahmed Kotb History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer Archivio Italiano di Urologia e Andrologia BCG Non-muscle invasive bladder cancer (NMIBT) Bladder cancer |
| title | History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer |
| title_full | History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer |
| title_fullStr | History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer |
| title_full_unstemmed | History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer |
| title_short | History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer |
| title_sort | history of infantile bcg immunization did not predict lamina propria invasion and or high grade in patients with non muscle invasive bladder cancer |
| topic | BCG Non-muscle invasive bladder cancer (NMIBT) Bladder cancer |
| url | https://pagepressjournals.org/index.php/aiua/article/view/11380 |
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