Computational design of a PDZ domain peptide inhibitor that rescues CFTR activity.

Computational design of a PDZ domain peptide inhibitor that rescues CFTR activity.

The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial chloride channel mutated in patients with cystic fibrosis (CF). The most prevalent CFTR mutation, ΔF508, blocks folding in the endoplasmic reticulum. Recent work has shown that some ΔF508-CFTR channel activity can be rec...

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Bibliographic Details
Main Authors: Kyle E Roberts, Patrick R Cushing, Prisca Boisguerin, Dean R Madden, Bruce R Donald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3330111?pdf=render

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