Exploration of Pyrido[3,4-<i>d</i>]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2

Exploration of Pyrido[3,4-<i>d</i>]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2

Upregulated CXCR2 signalling is found in numerous inflammatory, autoimmune and neurodegenerative diseases, as well as in cancer. Consequently, CXCR2 antagonism is a promising therapeutic strategy for treatment of these disorders. We previously identified, via scaffold hopping, a pyrido[3,4-<i>...

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Bibliographic Details
Main Authors:	Max Van Hoof, Sandra Claes, Katrijn Boon, Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Molecules
Subjects:	CXCR2 antagonists pyrido[3,4-<i>d</i>]pyrimidines SAR study
Online Access:	https://www.mdpi.com/1420-3049/28/5/2099

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