Structural Brain Network Abnormalities in Parkinson’s Disease With Freezing of Gait
ObjectiveDiffusion tensor imaging (DTI) studies have investigated white matter (WM) integrity abnormalities in Parkinson’s disease (PD). However, little is known about the topological changes in the brain network. This study aims to reveal these changes by comparing PD without freezing of gait (FOG)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.944925/full |
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| author | Chaoyang Jin Lei Yang Shouliang Qi Shouliang Qi Yueyang Teng Chen Li Yudong Yao Xiuhang Ruan Xinhua Wei |
| author_facet | Chaoyang Jin Lei Yang Shouliang Qi Shouliang Qi Yueyang Teng Chen Li Yudong Yao Xiuhang Ruan Xinhua Wei |
| author_sort | Chaoyang Jin |
| collection | DOAJ |
| description | ObjectiveDiffusion tensor imaging (DTI) studies have investigated white matter (WM) integrity abnormalities in Parkinson’s disease (PD). However, little is known about the topological changes in the brain network. This study aims to reveal these changes by comparing PD without freezing of gait (FOG) (PD FOG–), PD with FOG (PD FOG+), and healthy control (HC).Methods21 PD FOG+, 34 PD FOG-, and 23 HC were recruited, and DTI images were acquired. The graph theoretical analysis and network-based statistical method were used to calculate the topological parameters and assess connections.ResultsPD FOG+ showed a decreased normalized clustering coefficient, small-worldness, clustering coefficient, and increased local network efficiency compared with HCs. PD FOG+ showed decreased centrality, degree centrality, and nodal efficiency in the striatum, frontal gyrus, and supplementary motor area (SMA). PD FOG+ showed decreased connections in the frontal gyrus, cingulate gyrus, and caudate nucleus (CAU). The between centrality of the left SMA and left CAU was negatively correlated with FOG questionnaire scores.ConclusionThis study demonstrates that PD FOG+ exhibits disruption of global and local topological organization in structural brain networks, and the disrupted topological organization can be potential biomarkers in PD FOG+. These new findings may provide increasing insight into the pathophysiological mechanism of PD FOG+. |
| first_indexed | 2024-12-11T18:30:23Z |
| format | Article |
| id | doaj.art-460d50f955ae4b85a3a509c947c060f5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-11T18:30:23Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-460d50f955ae4b85a3a509c947c060f52022-12-22T00:54:56ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-07-011410.3389/fnagi.2022.944925944925Structural Brain Network Abnormalities in Parkinson’s Disease With Freezing of GaitChaoyang Jin0Lei Yang1Shouliang Qi2Shouliang Qi3Yueyang Teng4Chen Li5Yudong Yao6Xiuhang Ruan7Xinhua Wei8College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, ChinaCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, ChinaCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, ChinaKey Laboratory of Intelligent Computing in Medical Image, Ministry of Education, Northeastern University, Shenyang, ChinaCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, ChinaCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, ChinaDepartment of Electrical and Computer Engineering, Stevens Institute of Technology, Hoboken, NJ, United StatesDepartment of Radiology, School of Medicine, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou, ChinaDepartment of Radiology, School of Medicine, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou, ChinaObjectiveDiffusion tensor imaging (DTI) studies have investigated white matter (WM) integrity abnormalities in Parkinson’s disease (PD). However, little is known about the topological changes in the brain network. This study aims to reveal these changes by comparing PD without freezing of gait (FOG) (PD FOG–), PD with FOG (PD FOG+), and healthy control (HC).Methods21 PD FOG+, 34 PD FOG-, and 23 HC were recruited, and DTI images were acquired. The graph theoretical analysis and network-based statistical method were used to calculate the topological parameters and assess connections.ResultsPD FOG+ showed a decreased normalized clustering coefficient, small-worldness, clustering coefficient, and increased local network efficiency compared with HCs. PD FOG+ showed decreased centrality, degree centrality, and nodal efficiency in the striatum, frontal gyrus, and supplementary motor area (SMA). PD FOG+ showed decreased connections in the frontal gyrus, cingulate gyrus, and caudate nucleus (CAU). The between centrality of the left SMA and left CAU was negatively correlated with FOG questionnaire scores.ConclusionThis study demonstrates that PD FOG+ exhibits disruption of global and local topological organization in structural brain networks, and the disrupted topological organization can be potential biomarkers in PD FOG+. These new findings may provide increasing insight into the pathophysiological mechanism of PD FOG+.https://www.frontiersin.org/articles/10.3389/fnagi.2022.944925/fullParkinson’s diseasefreezing of gaitdiffusion tensor imaginggraph theory analysisnetwork-based statistic |
| spellingShingle | Chaoyang Jin Lei Yang Shouliang Qi Shouliang Qi Yueyang Teng Chen Li Yudong Yao Xiuhang Ruan Xinhua Wei Structural Brain Network Abnormalities in Parkinson’s Disease With Freezing of Gait Frontiers in Aging Neuroscience Parkinson’s disease freezing of gait diffusion tensor imaging graph theory analysis network-based statistic |
| title | Structural Brain Network Abnormalities in Parkinson’s Disease With Freezing of Gait |
| title_full | Structural Brain Network Abnormalities in Parkinson’s Disease With Freezing of Gait |
| title_fullStr | Structural Brain Network Abnormalities in Parkinson’s Disease With Freezing of Gait |
| title_full_unstemmed | Structural Brain Network Abnormalities in Parkinson’s Disease With Freezing of Gait |
| title_short | Structural Brain Network Abnormalities in Parkinson’s Disease With Freezing of Gait |
| title_sort | structural brain network abnormalities in parkinson s disease with freezing of gait |
| topic | Parkinson’s disease freezing of gait diffusion tensor imaging graph theory analysis network-based statistic |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.944925/full |
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