Leonurine suppresses prostate cancer growth in vitro and in vivo by regulating miR-18a-5p/SLC40A1 axis
Prostate cancer is a leading cause of cancer-associated death in males. Leonurine (Leo) is a pleiotropic anti-tumor agent isolated from traditional Chinese herb that was used in gynecologic treatments. However, its pharmacological effect against prostate cancer progression remains unclear. Here, we...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Chinese Journal of Physiology |
| Subjects: | |
| Online Access: | http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2022;volume=65;issue=6;spage=319;epage=327;aulast=Liang |
| _version_ | 1828066297221480448 |
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| author | Bin Liang Shouxi Cui Songnian Zou |
| author_facet | Bin Liang Shouxi Cui Songnian Zou |
| author_sort | Bin Liang |
| collection | DOAJ |
| description | Prostate cancer is a leading cause of cancer-associated death in males. Leonurine (Leo) is a pleiotropic anti-tumor agent isolated from traditional Chinese herb that was used in gynecologic treatments. However, its pharmacological effect against prostate cancer progression remains unclear. Here, we showed that Leo dose dependently inhibited prostate cancer cell proliferation, promoted cell apoptosis, and induced cell cycle arrest. Moreover, we noticed that miR-18a-5p was downregulated and the solute carrier family 40 member 1 (SLC40A1) is upregulated by Leo treatment. SLC40A1 knockdown by siRNA abrogated the inhibitory effect of Leo on prostate cancer progression. Notably, Leo also significantly inhibited prostate cancer progression in a subcutaneous xenograft tumor mouse model in vivo. This study further unveiled the mechanism by which Leo inhibited prostate cancer progression, which provides a promising potential for its future clinical application. |
| first_indexed | 2024-04-10T23:28:21Z |
| format | Article |
| id | doaj.art-460da9e149374f79a8d7336314bd348a |
| institution | Directory Open Access Journal |
| issn | 0304-4920 2666-0059 |
| language | English |
| last_indexed | 2024-04-10T23:28:21Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Chinese Journal of Physiology |
| spelling | doaj.art-460da9e149374f79a8d7336314bd348a2023-01-12T11:16:37ZengWolters Kluwer Medknow PublicationsChinese Journal of Physiology0304-49202666-00592022-01-0165631932710.4103/0304-4920.365459Leonurine suppresses prostate cancer growth in vitro and in vivo by regulating miR-18a-5p/SLC40A1 axisBin LiangShouxi CuiSongnian ZouProstate cancer is a leading cause of cancer-associated death in males. Leonurine (Leo) is a pleiotropic anti-tumor agent isolated from traditional Chinese herb that was used in gynecologic treatments. However, its pharmacological effect against prostate cancer progression remains unclear. Here, we showed that Leo dose dependently inhibited prostate cancer cell proliferation, promoted cell apoptosis, and induced cell cycle arrest. Moreover, we noticed that miR-18a-5p was downregulated and the solute carrier family 40 member 1 (SLC40A1) is upregulated by Leo treatment. SLC40A1 knockdown by siRNA abrogated the inhibitory effect of Leo on prostate cancer progression. Notably, Leo also significantly inhibited prostate cancer progression in a subcutaneous xenograft tumor mouse model in vivo. This study further unveiled the mechanism by which Leo inhibited prostate cancer progression, which provides a promising potential for its future clinical application.http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2022;volume=65;issue=6;spage=319;epage=327;aulast=Liangleonurinemir-18a-5pprostate cancersolute carrier family 40 member 1 |
| spellingShingle | Bin Liang Shouxi Cui Songnian Zou Leonurine suppresses prostate cancer growth in vitro and in vivo by regulating miR-18a-5p/SLC40A1 axis Chinese Journal of Physiology leonurine mir-18a-5p prostate cancer solute carrier family 40 member 1 |
| title | Leonurine suppresses prostate cancer growth in vitro and in vivo by regulating miR-18a-5p/SLC40A1 axis |
| title_full | Leonurine suppresses prostate cancer growth in vitro and in vivo by regulating miR-18a-5p/SLC40A1 axis |
| title_fullStr | Leonurine suppresses prostate cancer growth in vitro and in vivo by regulating miR-18a-5p/SLC40A1 axis |
| title_full_unstemmed | Leonurine suppresses prostate cancer growth in vitro and in vivo by regulating miR-18a-5p/SLC40A1 axis |
| title_short | Leonurine suppresses prostate cancer growth in vitro and in vivo by regulating miR-18a-5p/SLC40A1 axis |
| title_sort | leonurine suppresses prostate cancer growth in vitro and in vivo by regulating mir 18a 5p slc40a1 axis |
| topic | leonurine mir-18a-5p prostate cancer solute carrier family 40 member 1 |
| url | http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2022;volume=65;issue=6;spage=319;epage=327;aulast=Liang |
| work_keys_str_mv | AT binliang leonurinesuppressesprostatecancergrowthinvitroandinvivobyregulatingmir18a5pslc40a1axis AT shouxicui leonurinesuppressesprostatecancergrowthinvitroandinvivobyregulatingmir18a5pslc40a1axis AT songnianzou leonurinesuppressesprostatecancergrowthinvitroandinvivobyregulatingmir18a5pslc40a1axis |