Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new material study
Purpose: To investigate whether the use of absorble AZ31B magnesium alloys over distraction gaps improves the quality and quantity of regenerated bone better than the use of Collagen membranes. Methods: Fifteen mixed-breed dogs were randomly divided into the experimental (n = 10) and control (n = 5)...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023052404 |
| _version_ | 1797733057946451968 |
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| author | Guiran Zhao Shu Wang Guijun Wang Bin Zhang Han Huang Yusheng Yao |
| author_facet | Guiran Zhao Shu Wang Guijun Wang Bin Zhang Han Huang Yusheng Yao |
| author_sort | Guiran Zhao |
| collection | DOAJ |
| description | Purpose: To investigate whether the use of absorble AZ31B magnesium alloys over distraction gaps improves the quality and quantity of regenerated bone better than the use of Collagen membranes. Methods: Fifteen mixed-breed dogs were randomly divided into the experimental (n = 10) and control (n = 5) groups. In the experimental group, two devices were implanted along the mandible; one side with absorble AZ31B and the other side with Collagen. The control animals did not undergo osteotomy or distraction. After a consolidation time of two months, 30 specimens were harvested, and newly created bone was identified using CBCT and micro-CT. Results: The Collagen membranes were absorbed completely, and the AZ31B membranes became irregular and rough. Mandible length was successfully extended approximately 1 cm. More bone formation was found after using AZ31B than Collagen, and there was a significant difference in width reduction between experimental sites treated with AZ31B (0.11 ± 0.04 cm) and Collagen (0.42 ± 0.06 cm) (p < 0.05). Trabecular thickness was also significantly higher in AZ31B (0.338 ± 0.08 cm) and control (0.417 ± 0.05 cm) than Collagen (0.178 ± 0.04 cm) (p < 0.05). Conclusion: An AZ31B membrane barrier is biocompatible and absorbable which can maintain the distraction gap and provide support to the attached osteoprogenitors by providing space for them to proliferate. |
| first_indexed | 2024-03-12T12:23:34Z |
| format | Article |
| id | doaj.art-461189833a144f11b90eeeb3534c9d6e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T12:23:34Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-461189833a144f11b90eeeb3534c9d6e2023-08-30T05:50:54ZengElsevierHeliyon2405-84402023-08-0198e18032Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new material studyGuiran Zhao0Shu Wang1Guijun Wang2Bin Zhang3Han Huang4Yusheng Yao5Department of Oral and Maxillofacial Surgery. First Affiliated Hospital of Jinzhou Medical University, Jinzhou City, Liaoning Province, ChinaSecond Affiliated Hospital of Jinzhou Medical University, Jinzhou City, Liaoning Province, ChinaFirst Affiliated Hospital of Jinzhou Medical University, Jinzhou City, Liaoning Province, ChinaFirst Affiliated Hospital of Jinzhou Medical University, Jinzhou City, Liaoning Province, ChinaFirst Affiliated Hospital of Jinzhou Medical University, Jinzhou City, Liaoning Province, ChinaThird Affiliated Hospital of Jinzhou Medical University, No.2, Section5, Heping Road, Linghe District, Jinzhou City, Liaoning Province, China; Corresponding author.Purpose: To investigate whether the use of absorble AZ31B magnesium alloys over distraction gaps improves the quality and quantity of regenerated bone better than the use of Collagen membranes. Methods: Fifteen mixed-breed dogs were randomly divided into the experimental (n = 10) and control (n = 5) groups. In the experimental group, two devices were implanted along the mandible; one side with absorble AZ31B and the other side with Collagen. The control animals did not undergo osteotomy or distraction. After a consolidation time of two months, 30 specimens were harvested, and newly created bone was identified using CBCT and micro-CT. Results: The Collagen membranes were absorbed completely, and the AZ31B membranes became irregular and rough. Mandible length was successfully extended approximately 1 cm. More bone formation was found after using AZ31B than Collagen, and there was a significant difference in width reduction between experimental sites treated with AZ31B (0.11 ± 0.04 cm) and Collagen (0.42 ± 0.06 cm) (p < 0.05). Trabecular thickness was also significantly higher in AZ31B (0.338 ± 0.08 cm) and control (0.417 ± 0.05 cm) than Collagen (0.178 ± 0.04 cm) (p < 0.05). Conclusion: An AZ31B membrane barrier is biocompatible and absorbable which can maintain the distraction gap and provide support to the attached osteoprogenitors by providing space for them to proliferate.http://www.sciencedirect.com/science/article/pii/S2405844023052404Distraction osteogenesisAbsorbleAZ31B magnesium alloy |
| spellingShingle | Guiran Zhao Shu Wang Guijun Wang Bin Zhang Han Huang Yusheng Yao Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new material study Heliyon Distraction osteogenesis Absorble AZ31B magnesium alloy |
| title | Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new material study |
| title_full | Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new material study |
| title_fullStr | Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new material study |
| title_full_unstemmed | Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new material study |
| title_short | Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new material study |
| title_sort | enhancing bone formation using absorbable az31b magnesium alloy membranes during distraction osteogenesis a new material study |
| topic | Distraction osteogenesis Absorble AZ31B magnesium alloy |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023052404 |
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