A practical guide to pharmaceutical polymorph screening & selection
Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery and development. This review introduces the basic concepts of “What is polymorphism?”, addresse...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-08-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087614000245 |
| _version_ | 1828874775579066368 |
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| author | Eun Hee Lee |
| author_facet | Eun Hee Lee |
| author_sort | Eun Hee Lee |
| collection | DOAJ |
| description | Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery and development. This review introduces the basic concepts of “What is polymorphism?”, addresses a fundamental question of “Why do polymorphs form?”, and provides practical guidelines of “How to prepare polymorphs?” “How to evaluate the relative thermodynamic stability between polymorphs?”, and “How to analyze polymorphs?”. Moreover, case studies of pharmaceutically important polymorphs are provided. |
| first_indexed | 2024-12-13T07:45:05Z |
| format | Article |
| id | doaj.art-46147949916244e2a295ae9d5c1b7df9 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-13T07:45:05Z |
| publishDate | 2014-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-46147949916244e2a295ae9d5c1b7df92022-12-21T23:54:52ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762014-08-019416317510.1016/j.ajps.2014.05.002A practical guide to pharmaceutical polymorph screening & selectionEun Hee LeePrevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery and development. This review introduces the basic concepts of “What is polymorphism?”, addresses a fundamental question of “Why do polymorphs form?”, and provides practical guidelines of “How to prepare polymorphs?” “How to evaluate the relative thermodynamic stability between polymorphs?”, and “How to analyze polymorphs?”. Moreover, case studies of pharmaceutically important polymorphs are provided.http://www.sciencedirect.com/science/article/pii/S1818087614000245PolymorphsPolymorph screeningPolymorph selectionPolymorph preparation |
| spellingShingle | Eun Hee Lee A practical guide to pharmaceutical polymorph screening & selection Asian Journal of Pharmaceutical Sciences Polymorphs Polymorph screening Polymorph selection Polymorph preparation |
| title | A practical guide to pharmaceutical polymorph screening & selection |
| title_full | A practical guide to pharmaceutical polymorph screening & selection |
| title_fullStr | A practical guide to pharmaceutical polymorph screening & selection |
| title_full_unstemmed | A practical guide to pharmaceutical polymorph screening & selection |
| title_short | A practical guide to pharmaceutical polymorph screening & selection |
| title_sort | practical guide to pharmaceutical polymorph screening selection |
| topic | Polymorphs Polymorph screening Polymorph selection Polymorph preparation |
| url | http://www.sciencedirect.com/science/article/pii/S1818087614000245 |
| work_keys_str_mv | AT eunheelee apracticalguidetopharmaceuticalpolymorphscreeningselection AT eunheelee practicalguidetopharmaceuticalpolymorphscreeningselection |