Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas
Glioblastomas are highly diffuse, malignant tumors that have so far evaded clinical treatment. The strongly invasive behavior of cells in these tumors makes them very resistant to treatment, and for this reason both experimental and theoretical efforts have been directed toward understanding the spa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
IOP Publishing
2013-01-01
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| Series: | New Journal of Physics |
| Online Access: | https://doi.org/10.1088/1367-2630/15/5/055001 |
| _version_ | 1827874385941233664 |
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| author | Joaquim Fort Ricard V Solé |
| author_facet | Joaquim Fort Ricard V Solé |
| author_sort | Joaquim Fort |
| collection | DOAJ |
| description | Glioblastomas are highly diffuse, malignant tumors that have so far evaded clinical treatment. The strongly invasive behavior of cells in these tumors makes them very resistant to treatment, and for this reason both experimental and theoretical efforts have been directed toward understanding the spatiotemporal pattern of tumor spreading. Although usual models assume a standard diffusion behavior, recent experiments with cell cultures indicate that cells tend to move in directions close to that of glioblastoma invasion, thus indicating that a biased random walk model may be much more appropriate. Here we show analytically that, for realistic parameter values, the speeds predicted by biased dispersal are consistent with experimentally measured data. We also find that models beyond reaction–diffusion–advection equations are necessary to capture this substantial effect of biased dispersal on glioblastoma spread. |
| first_indexed | 2024-03-12T16:51:31Z |
| format | Article |
| id | doaj.art-461778b2e4f4437380080509670b754a |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:51:31Z |
| publishDate | 2013-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-461778b2e4f4437380080509670b754a2023-08-08T11:08:35ZengIOP PublishingNew Journal of Physics1367-26302013-01-0115505500110.1088/1367-2630/15/5/055001Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomasJoaquim Fort0Ricard V Solé1Complex Systems Lab and Physics Department, EPS, Universitat de Girona , E-17071 Girona, Catalonia, SpainICREA-Complex Systems Lab, Universitat Pompeu Fabra (GRIB) , Dr Aiguader 80, E-08003 Barcelona, Catalonia, Spain; Institut de Biologia Evolutiva , CSIC-UPF, E-08003 Barcelona, Catalonia, Spain; Santa Fe Institute , Santa Fe, NM 87501, USAGlioblastomas are highly diffuse, malignant tumors that have so far evaded clinical treatment. The strongly invasive behavior of cells in these tumors makes them very resistant to treatment, and for this reason both experimental and theoretical efforts have been directed toward understanding the spatiotemporal pattern of tumor spreading. Although usual models assume a standard diffusion behavior, recent experiments with cell cultures indicate that cells tend to move in directions close to that of glioblastoma invasion, thus indicating that a biased random walk model may be much more appropriate. Here we show analytically that, for realistic parameter values, the speeds predicted by biased dispersal are consistent with experimentally measured data. We also find that models beyond reaction–diffusion–advection equations are necessary to capture this substantial effect of biased dispersal on glioblastoma spread.https://doi.org/10.1088/1367-2630/15/5/055001 |
| spellingShingle | Joaquim Fort Ricard V Solé Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas New Journal of Physics |
| title | Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas |
| title_full | Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas |
| title_fullStr | Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas |
| title_full_unstemmed | Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas |
| title_short | Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas |
| title_sort | accelerated tumor invasion under non isotropic cell dispersal in glioblastomas |
| url | https://doi.org/10.1088/1367-2630/15/5/055001 |
| work_keys_str_mv | AT joaquimfort acceleratedtumorinvasionundernonisotropiccelldispersalinglioblastomas AT ricardvsole acceleratedtumorinvasionundernonisotropiccelldispersalinglioblastomas |