The association of myositis specific antibodies in patients with inflammatory myositis: Preliminary data in Indian patients
Context: Autoantibodies have a role in the diagnosis and prognosis in Autoimmune Inflammatory Myositis (AIM). Aims: The aim of this work was to study the prevalence and clinical correlation of myositis specific and associated antibodies (MSA and MAA) in AIM. Setting and Design: This was a cross-sect...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Annals of Indian Academy of Neurology |
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| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2021;volume=24;issue=4;spage=552;epage=558;aulast=Negalur |
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| author | Natasha Vijay Negalur Gayatri G Ekbote Dhiren N Raval Dhaval V Tanna Wasim S Kazi Muzaffar A Bindroo Durgarao J Yadavalli Rajiva Gupta |
| author_facet | Natasha Vijay Negalur Gayatri G Ekbote Dhiren N Raval Dhaval V Tanna Wasim S Kazi Muzaffar A Bindroo Durgarao J Yadavalli Rajiva Gupta |
| author_sort | Natasha Vijay Negalur |
| collection | DOAJ |
| description | Context: Autoantibodies have a role in the diagnosis and prognosis in Autoimmune Inflammatory Myositis (AIM). Aims: The aim of this work was to study the prevalence and clinical correlation of myositis specific and associated antibodies (MSA and MAA) in AIM. Setting and Design: This was a cross-sectional observational study. Methods and Materials: Consecutive AIM patents were divided into groups as dermatomyositis (DM), polymyositis (PM), CTD-associated myositis (CTD-M), cancer-associated myositis (CAM) and juvenile myositis (JM). Their data along with serum samples were collected after obtaining informed consent. Sera was analyzed for IgG antibodies against Jo-1, PL-7, PL-12, EJ, SRP, Mi-2, MDA-5, TIF1γ, SAE1, SAE2, NXP2 and SSA/R052kD using the microELISA technique. The institutional ethics committee approved the study. Statistical Analysis: SPSS software (version 24.0) was used. P value < 0.05 was considered statistically significant. Results: There were 48 patients (DM = 19, PM = 19, CTD-M = 5, CAM = 2, JM = 3) included. MSA were positive in 37.5% patients. Antibodies against Mi-2 were present in 6 (12.5%), Jo-1 in 5 (10.4%), 2 (4.1%) each had PL-7 and SRP antibodies. One patient (2%) each had MDA-5, NXP2 and TIf1g antibodies. Jo-1 antibody was associated with mechanic's hands and ILD. There was a significant association of rash in the Mi-2 group with none of the patients having ILD. Malignancy screening was negative in NXP2 and TIF1g antibody-positive patients. Ro52 was the most common MAA (33.3%) and was associated with mechanic's hand. Conclusion: MSA was present in almost 40% of the cohort. Anti Jo-1 antibody was associated with mechanic's hands and ILD. None of the Mi-2 patients had ILD, which may point to a protective role of this antibody for ILD. The association of newer antibodies in Indian patients needs to be further studied in larger cohorts. |
| first_indexed | 2024-12-16T09:32:12Z |
| format | Article |
| id | doaj.art-4617bfd88bd641f2b6e801227179a5d2 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-16T09:32:12Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-4617bfd88bd641f2b6e801227179a5d22022-12-21T22:36:29ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492021-01-0124455255810.4103/aian.AIAN_1151_20The association of myositis specific antibodies in patients with inflammatory myositis: Preliminary data in Indian patientsNatasha Vijay NegalurGayatri G EkboteDhiren N RavalDhaval V TannaWasim S KaziMuzaffar A BindrooDurgarao J YadavalliRajiva GuptaContext: Autoantibodies have a role in the diagnosis and prognosis in Autoimmune Inflammatory Myositis (AIM). Aims: The aim of this work was to study the prevalence and clinical correlation of myositis specific and associated antibodies (MSA and MAA) in AIM. Setting and Design: This was a cross-sectional observational study. Methods and Materials: Consecutive AIM patents were divided into groups as dermatomyositis (DM), polymyositis (PM), CTD-associated myositis (CTD-M), cancer-associated myositis (CAM) and juvenile myositis (JM). Their data along with serum samples were collected after obtaining informed consent. Sera was analyzed for IgG antibodies against Jo-1, PL-7, PL-12, EJ, SRP, Mi-2, MDA-5, TIF1γ, SAE1, SAE2, NXP2 and SSA/R052kD using the microELISA technique. The institutional ethics committee approved the study. Statistical Analysis: SPSS software (version 24.0) was used. P value < 0.05 was considered statistically significant. Results: There were 48 patients (DM = 19, PM = 19, CTD-M = 5, CAM = 2, JM = 3) included. MSA were positive in 37.5% patients. Antibodies against Mi-2 were present in 6 (12.5%), Jo-1 in 5 (10.4%), 2 (4.1%) each had PL-7 and SRP antibodies. One patient (2%) each had MDA-5, NXP2 and TIf1g antibodies. Jo-1 antibody was associated with mechanic's hands and ILD. There was a significant association of rash in the Mi-2 group with none of the patients having ILD. Malignancy screening was negative in NXP2 and TIF1g antibody-positive patients. Ro52 was the most common MAA (33.3%) and was associated with mechanic's hand. Conclusion: MSA was present in almost 40% of the cohort. Anti Jo-1 antibody was associated with mechanic's hands and ILD. None of the Mi-2 patients had ILD, which may point to a protective role of this antibody for ILD. The association of newer antibodies in Indian patients needs to be further studied in larger cohorts.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2021;volume=24;issue=4;spage=552;epage=558;aulast=Negalurantibodiesindianmda-5myositismyositis specific antibodiesnxp2tif1g |
| spellingShingle | Natasha Vijay Negalur Gayatri G Ekbote Dhiren N Raval Dhaval V Tanna Wasim S Kazi Muzaffar A Bindroo Durgarao J Yadavalli Rajiva Gupta The association of myositis specific antibodies in patients with inflammatory myositis: Preliminary data in Indian patients Annals of Indian Academy of Neurology antibodies indian mda-5 myositis myositis specific antibodies nxp2 tif1g |
| title | The association of myositis specific antibodies in patients with inflammatory myositis: Preliminary data in Indian patients |
| title_full | The association of myositis specific antibodies in patients with inflammatory myositis: Preliminary data in Indian patients |
| title_fullStr | The association of myositis specific antibodies in patients with inflammatory myositis: Preliminary data in Indian patients |
| title_full_unstemmed | The association of myositis specific antibodies in patients with inflammatory myositis: Preliminary data in Indian patients |
| title_short | The association of myositis specific antibodies in patients with inflammatory myositis: Preliminary data in Indian patients |
| title_sort | association of myositis specific antibodies in patients with inflammatory myositis preliminary data in indian patients |
| topic | antibodies indian mda-5 myositis myositis specific antibodies nxp2 tif1g |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2021;volume=24;issue=4;spage=552;epage=558;aulast=Negalur |
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