Adverse radiation effect in the brain during cancer radiotherapy
Adverse radiation effect (ARE) in the brain is the reactive inflammation, vasculitis, and necrosis that occurs as a complication of radiotherapy. There are two main categories of ARE that result in vasogenic cerebral edema: first, a residual irritant mass of the targeted lesion; and second, radiatio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Radiation and Cancer Research |
| Subjects: | |
| Online Access: | http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=3;spage=135;epage=140;aulast=Fabiano |
| _version_ | 1828368736433733632 |
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| author | Andrew J Fabiano Dheerendra Prasad Jingxin Qiu |
| author_facet | Andrew J Fabiano Dheerendra Prasad Jingxin Qiu |
| author_sort | Andrew J Fabiano |
| collection | DOAJ |
| description | Adverse radiation effect (ARE) in the brain is the reactive inflammation, vasculitis, and necrosis that occurs as a complication of radiotherapy. There are two main categories of ARE that result in vasogenic cerebral edema: first, a residual irritant mass of the targeted lesion; and second, radiation-damaged perilesional normal brain tissue in a reactive state. Radiation injury leads to fibrinoid and coagulative necrosis of different cell types and fibrinoid necrosis and hyalinization of vessels. The clinical consequence of ARE is neurologic impairment secondary to vasogenic edema in the normal brain. Neuroimaging may aid in differentiating tumor recurrence from ARE. However, imaging studies are not definitive, and their utility in this setting remains controversial. The management of patients with ARE is dictated by symptom occurrence. The definitive management of symptomatic ARE is craniotomy and resection. Alternative therapies include bevacizumab, laser-interstitial thermal therapy, and reirradiation. |
| first_indexed | 2024-04-14T06:14:45Z |
| format | Article |
| id | doaj.art-4617d775438b409e82f5fa274a6903c7 |
| institution | Directory Open Access Journal |
| issn | 2588-9273 2468-9203 |
| language | English |
| last_indexed | 2024-04-14T06:14:45Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Radiation and Cancer Research |
| spelling | doaj.art-4617d775438b409e82f5fa274a6903c72022-12-22T02:08:14ZengWolters Kluwer Medknow PublicationsJournal of Radiation and Cancer Research2588-92732468-92032017-01-018313514010.4103/jrcr.jrcr_33_17Adverse radiation effect in the brain during cancer radiotherapyAndrew J FabianoDheerendra PrasadJingxin QiuAdverse radiation effect (ARE) in the brain is the reactive inflammation, vasculitis, and necrosis that occurs as a complication of radiotherapy. There are two main categories of ARE that result in vasogenic cerebral edema: first, a residual irritant mass of the targeted lesion; and second, radiation-damaged perilesional normal brain tissue in a reactive state. Radiation injury leads to fibrinoid and coagulative necrosis of different cell types and fibrinoid necrosis and hyalinization of vessels. The clinical consequence of ARE is neurologic impairment secondary to vasogenic edema in the normal brain. Neuroimaging may aid in differentiating tumor recurrence from ARE. However, imaging studies are not definitive, and their utility in this setting remains controversial. The management of patients with ARE is dictated by symptom occurrence. The definitive management of symptomatic ARE is craniotomy and resection. Alternative therapies include bevacizumab, laser-interstitial thermal therapy, and reirradiation.http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=3;spage=135;epage=140;aulast=FabianoAdverse radiation effectbrainnecrosisradiation |
| spellingShingle | Andrew J Fabiano Dheerendra Prasad Jingxin Qiu Adverse radiation effect in the brain during cancer radiotherapy Journal of Radiation and Cancer Research Adverse radiation effect brain necrosis radiation |
| title | Adverse radiation effect in the brain during cancer radiotherapy |
| title_full | Adverse radiation effect in the brain during cancer radiotherapy |
| title_fullStr | Adverse radiation effect in the brain during cancer radiotherapy |
| title_full_unstemmed | Adverse radiation effect in the brain during cancer radiotherapy |
| title_short | Adverse radiation effect in the brain during cancer radiotherapy |
| title_sort | adverse radiation effect in the brain during cancer radiotherapy |
| topic | Adverse radiation effect brain necrosis radiation |
| url | http://www.journalrcr.org/article.asp?issn=0973-0168;year=2017;volume=8;issue=3;spage=135;epage=140;aulast=Fabiano |
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