YTHDF1 in Tumor Cell Metabolism: An Updated Review
With the advancement of research on m6A-related mechanisms in recent years, the YTHDF protein family within m6A readers has garnered significant attention. Among them, YTHDF1 serves as a pivotal member, playing a crucial role in protein translation, tumor proliferation, metabolic reprogramming of va...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/1/140 |
| _version_ | 1797358386942050304 |
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| author | Haichuan Rong Danyang Wang Yiran Wang Chenshuang Dong Guiling Wang |
| author_facet | Haichuan Rong Danyang Wang Yiran Wang Chenshuang Dong Guiling Wang |
| author_sort | Haichuan Rong |
| collection | DOAJ |
| description | With the advancement of research on m6A-related mechanisms in recent years, the YTHDF protein family within m6A readers has garnered significant attention. Among them, YTHDF1 serves as a pivotal member, playing a crucial role in protein translation, tumor proliferation, metabolic reprogramming of various tumor cells, and immune evasion. In addition, YTHDF1 also exerts regulatory effects on tumors through multiple signaling pathways, and numerous studies have confirmed its ability to assist in the reprogramming of the tumor cell-related metabolic processes. The focus of research on YTHDF1 has shifted in recent years from its m6A-recognition and -modification function to the molecular mechanisms by which it regulates tumor progression, particularly by exploring the regulatory factors that interact with YTHDF1 upstream and downstream. In this review, we elucidate the latest signaling pathway mechanisms of YTHDF1 in various tumor cells, with a special emphasis on its distinctive characteristics in tumor cell metabolic reprogramming. Furthermore, we summarize the latest pathological and physiological processes involving YTHDF1 in tumor cells, and analyze potential therapeutic approaches that utilize YTHDF1. We believe that YTHDF1 represents a highly promising target for future tumor treatments and a novel tumor biomarker. |
| first_indexed | 2024-03-08T15:01:13Z |
| format | Article |
| id | doaj.art-4618d5e1609f4e47996638ffe6c9dffd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T15:01:13Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4618d5e1609f4e47996638ffe6c9dffd2024-01-10T15:04:17ZengMDPI AGMolecules1420-30492023-12-0129114010.3390/molecules29010140YTHDF1 in Tumor Cell Metabolism: An Updated ReviewHaichuan Rong0Danyang Wang1Yiran Wang2Chenshuang Dong3Guiling Wang4Key Laboratory of Cell Biology, Department of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, ChinaKey Laboratory of Cell Biology, Department of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, ChinaKey Laboratory of Cell Biology, Department of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, ChinaKey Laboratory of Cell Biology, Department of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, ChinaKey Laboratory of Cell Biology, Department of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, ChinaWith the advancement of research on m6A-related mechanisms in recent years, the YTHDF protein family within m6A readers has garnered significant attention. Among them, YTHDF1 serves as a pivotal member, playing a crucial role in protein translation, tumor proliferation, metabolic reprogramming of various tumor cells, and immune evasion. In addition, YTHDF1 also exerts regulatory effects on tumors through multiple signaling pathways, and numerous studies have confirmed its ability to assist in the reprogramming of the tumor cell-related metabolic processes. The focus of research on YTHDF1 has shifted in recent years from its m6A-recognition and -modification function to the molecular mechanisms by which it regulates tumor progression, particularly by exploring the regulatory factors that interact with YTHDF1 upstream and downstream. In this review, we elucidate the latest signaling pathway mechanisms of YTHDF1 in various tumor cells, with a special emphasis on its distinctive characteristics in tumor cell metabolic reprogramming. Furthermore, we summarize the latest pathological and physiological processes involving YTHDF1 in tumor cells, and analyze potential therapeutic approaches that utilize YTHDF1. We believe that YTHDF1 represents a highly promising target for future tumor treatments and a novel tumor biomarker.https://www.mdpi.com/1420-3049/29/1/140N6-methyladenosineYTHDF1metabolic reprogrammingcancer cellmolecular mechanisms |
| spellingShingle | Haichuan Rong Danyang Wang Yiran Wang Chenshuang Dong Guiling Wang YTHDF1 in Tumor Cell Metabolism: An Updated Review Molecules N6-methyladenosine YTHDF1 metabolic reprogramming cancer cell molecular mechanisms |
| title | YTHDF1 in Tumor Cell Metabolism: An Updated Review |
| title_full | YTHDF1 in Tumor Cell Metabolism: An Updated Review |
| title_fullStr | YTHDF1 in Tumor Cell Metabolism: An Updated Review |
| title_full_unstemmed | YTHDF1 in Tumor Cell Metabolism: An Updated Review |
| title_short | YTHDF1 in Tumor Cell Metabolism: An Updated Review |
| title_sort | ythdf1 in tumor cell metabolism an updated review |
| topic | N6-methyladenosine YTHDF1 metabolic reprogramming cancer cell molecular mechanisms |
| url | https://www.mdpi.com/1420-3049/29/1/140 |
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