Impaired Frontal Brain Activity in Patients With Heart Failure Assessed by Near‐Infrared Spectroscopy
Background The prevalence of depression and/or anxiety disorders is reported to be higher in patients with heart failure (HF) than in the general population, and patients with HF also have coexisting cognitive problems. Recently, the development of near‐infrared spectroscopy (NIRS) has enabled nonin...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.014564 |
| _version_ | 1818288082251677696 |
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| author | Yasuhiro Ichijo Soichi Kono Akiomi Yoshihisa Tomofumi Misaka Takashi Kaneshiro Masayoshi Oikawa Itaru Miura Hirooki Yabe Yasuchika Takeishi |
| author_facet | Yasuhiro Ichijo Soichi Kono Akiomi Yoshihisa Tomofumi Misaka Takashi Kaneshiro Masayoshi Oikawa Itaru Miura Hirooki Yabe Yasuchika Takeishi |
| author_sort | Yasuhiro Ichijo |
| collection | DOAJ |
| description | Background The prevalence of depression and/or anxiety disorders is reported to be higher in patients with heart failure (HF) than in the general population, and patients with HF also have coexisting cognitive problems. Recently, the development of near‐infrared spectroscopy (NIRS) has enabled noninvasive measurements of regional cerebral blood volume and brain activity, in terms of cerebral oxyhemoglobin in the cerebral cortex, with a high time resolution. The aim of the current study was to determine the associations between frontal brain activity and depressive symptoms, anxiety status, and cognitive function in patients with HF. Methods and Results We measured and compared frontal brain activity determined by NIRS during a verbal fluency task in patients with HF (n=35) and control subjects (n=28). The Center for Epidemiologic Studies Depression Scale for assessment of depressive symptoms, State‐Trait Anxiety Inventory for assessment of anxiety status, Mini‐Mental State Examination for assessment of cognitive function, and NIRS were simultaneously conducted. NIRS showed that frontal brain activity was significantly lower in the HF group than in the control subjects (28.5 versus 88.0 mM·mm; P<0.001). Next, we examined the associations between frontal brain activity and the findings of Center for Epidemiologic Studies Depression Scale, State‐Trait Anxiety Inventory, Mini‐Mental State Examination, and verbal fluency task. There were significant correlations between frontal brain activity and State‐Trait Anxiety Inventory (R=−0.228, P=0.046), Mini‐Mental State Examination (R=0.414, P=0.017), and verbal fluency task (R=0.338, P=0.007), but not with Center for Epidemiologic Studies Depression Scale (R=−0.160, P=0.233). Conclusions Frontal brain activity assessed by NIRS is reduced and is associated with high anxiety status and low cognitive function in patients with HF. |
| first_indexed | 2024-12-13T01:50:43Z |
| format | Article |
| id | doaj.art-46199ce16ae047b19e437f6324cedf14 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T01:50:43Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-46199ce16ae047b19e437f6324cedf142022-12-22T00:03:30ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-02-019310.1161/JAHA.119.014564Impaired Frontal Brain Activity in Patients With Heart Failure Assessed by Near‐Infrared SpectroscopyYasuhiro Ichijo0Soichi Kono1Akiomi Yoshihisa2Tomofumi Misaka3Takashi Kaneshiro4Masayoshi Oikawa5Itaru Miura6Hirooki Yabe7Yasuchika Takeishi8Department of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Neuropsychiatry Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Neuropsychiatry Fukushima Medical University Fukushima JapanDepartment of Neuropsychiatry Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanBackground The prevalence of depression and/or anxiety disorders is reported to be higher in patients with heart failure (HF) than in the general population, and patients with HF also have coexisting cognitive problems. Recently, the development of near‐infrared spectroscopy (NIRS) has enabled noninvasive measurements of regional cerebral blood volume and brain activity, in terms of cerebral oxyhemoglobin in the cerebral cortex, with a high time resolution. The aim of the current study was to determine the associations between frontal brain activity and depressive symptoms, anxiety status, and cognitive function in patients with HF. Methods and Results We measured and compared frontal brain activity determined by NIRS during a verbal fluency task in patients with HF (n=35) and control subjects (n=28). The Center for Epidemiologic Studies Depression Scale for assessment of depressive symptoms, State‐Trait Anxiety Inventory for assessment of anxiety status, Mini‐Mental State Examination for assessment of cognitive function, and NIRS were simultaneously conducted. NIRS showed that frontal brain activity was significantly lower in the HF group than in the control subjects (28.5 versus 88.0 mM·mm; P<0.001). Next, we examined the associations between frontal brain activity and the findings of Center for Epidemiologic Studies Depression Scale, State‐Trait Anxiety Inventory, Mini‐Mental State Examination, and verbal fluency task. There were significant correlations between frontal brain activity and State‐Trait Anxiety Inventory (R=−0.228, P=0.046), Mini‐Mental State Examination (R=0.414, P=0.017), and verbal fluency task (R=0.338, P=0.007), but not with Center for Epidemiologic Studies Depression Scale (R=−0.160, P=0.233). Conclusions Frontal brain activity assessed by NIRS is reduced and is associated with high anxiety status and low cognitive function in patients with HF.https://www.ahajournals.org/doi/10.1161/JAHA.119.014564anxietycognitive functiondementiadepressionheart failure |
| spellingShingle | Yasuhiro Ichijo Soichi Kono Akiomi Yoshihisa Tomofumi Misaka Takashi Kaneshiro Masayoshi Oikawa Itaru Miura Hirooki Yabe Yasuchika Takeishi Impaired Frontal Brain Activity in Patients With Heart Failure Assessed by Near‐Infrared Spectroscopy Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease anxiety cognitive function dementia depression heart failure |
| title | Impaired Frontal Brain Activity in Patients With Heart Failure Assessed by Near‐Infrared Spectroscopy |
| title_full | Impaired Frontal Brain Activity in Patients With Heart Failure Assessed by Near‐Infrared Spectroscopy |
| title_fullStr | Impaired Frontal Brain Activity in Patients With Heart Failure Assessed by Near‐Infrared Spectroscopy |
| title_full_unstemmed | Impaired Frontal Brain Activity in Patients With Heart Failure Assessed by Near‐Infrared Spectroscopy |
| title_short | Impaired Frontal Brain Activity in Patients With Heart Failure Assessed by Near‐Infrared Spectroscopy |
| title_sort | impaired frontal brain activity in patients with heart failure assessed by near infrared spectroscopy |
| topic | anxiety cognitive function dementia depression heart failure |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.014564 |
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