Aspergillus fumigatus melanins: Interference with the host endocytosis pathway and impact on virulence

Aspergillus fumigatus melanins: Interference with the host endocytosis pathway and impact on virulence

The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin. Pyomelanin is produced during tyrosine catabolism via accumulation of homogentisic acid. Although pyomelanin protects the fungus against r...

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Bibliographic Details
Main Authors: Thorsten eHeinekamp, Andreas eThywissen, Juliane eMacheleidt, Sophia eKeller, Vito eValiante, Axel A Brakhage
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Microbiology
Subjects:
Apoptosis
Aspergillus fumigatus
Endocytosis
Phagocytes
Virulence
melanin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00440/full

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