SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows
Endothelial activation in infectious diseases plays a crucial role in understanding and predicting the outcomes and future treatments of several clinical conditions. COVID-19 is no exception. Moving from basic principles to novel approaches, an evolving view of endothelial activation provides insigh...
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Format: | Article |
Language: | English |
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MDPI AG
2022-09-01
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Series: | Biomedicines |
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Online Access: | https://www.mdpi.com/2227-9059/10/9/2242 |
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author | Antonio Giovanni Solimando Donatello Marziliano Domenico Ribatti |
author_facet | Antonio Giovanni Solimando Donatello Marziliano Domenico Ribatti |
author_sort | Antonio Giovanni Solimando |
collection | DOAJ |
description | Endothelial activation in infectious diseases plays a crucial role in understanding and predicting the outcomes and future treatments of several clinical conditions. COVID-19 is no exception. Moving from basic principles to novel approaches, an evolving view of endothelial activation provides insights into a better knowledge of the upstream actors in COVID-19 as a crucial future direction for managing SARS-CoV-2 and other infections. Assessing the function of resting and damaged endothelial cells in infection, particularly in COVID-19, five critical processes emerged controlling thrombo-resistance: vascular integrity, blood flow regulation, immune cell trafficking, angiogenesis and intussusceptive microvascular growth. Endothelial cell injury is associated with thrombosis, increased vessel contraction and a crucial phenomenon identified as intussusceptive microvascular growth, an unprecedented event of vessel splitting into two lumens through the integration of circulating pro-angiogenic cells. An essential awareness of endothelial cells and their phenotypic changes in COVID-19 inflammation is pivotal to understanding the vascular biology of infections and may offer crucial new therapeutic windows. |
first_indexed | 2024-03-10T00:38:14Z |
format | Article |
id | doaj.art-461c10e3555e4faeba519286befa1dd9 |
institution | Directory Open Access Journal |
issn | 2227-9059 |
language | English |
last_indexed | 2024-03-10T00:38:14Z |
publishDate | 2022-09-01 |
publisher | MDPI AG |
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series | Biomedicines |
spelling | doaj.art-461c10e3555e4faeba519286befa1dd92023-11-23T15:11:32ZengMDPI AGBiomedicines2227-90592022-09-01109224210.3390/biomedicines10092242SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic WindowsAntonio Giovanni Solimando0Donatello Marziliano1Domenico Ribatti2Guido Baccelli Unit of Internal Medicine, Department of Biomedical Sciences and Human Oncology, School of Medicine, Aldo Moro University of Bari, 70124 Bari, ItalyGuido Baccelli Unit of Internal Medicine, Department of Biomedical Sciences and Human Oncology, School of Medicine, Aldo Moro University of Bari, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, 70124 Bari, ItalyEndothelial activation in infectious diseases plays a crucial role in understanding and predicting the outcomes and future treatments of several clinical conditions. COVID-19 is no exception. Moving from basic principles to novel approaches, an evolving view of endothelial activation provides insights into a better knowledge of the upstream actors in COVID-19 as a crucial future direction for managing SARS-CoV-2 and other infections. Assessing the function of resting and damaged endothelial cells in infection, particularly in COVID-19, five critical processes emerged controlling thrombo-resistance: vascular integrity, blood flow regulation, immune cell trafficking, angiogenesis and intussusceptive microvascular growth. Endothelial cell injury is associated with thrombosis, increased vessel contraction and a crucial phenomenon identified as intussusceptive microvascular growth, an unprecedented event of vessel splitting into two lumens through the integration of circulating pro-angiogenic cells. An essential awareness of endothelial cells and their phenotypic changes in COVID-19 inflammation is pivotal to understanding the vascular biology of infections and may offer crucial new therapeutic windows.https://www.mdpi.com/2227-9059/10/9/2242angiogenesisinfectionsSARS-CoV-2COVID-19intussusceptive microvascular growth |
spellingShingle | Antonio Giovanni Solimando Donatello Marziliano Domenico Ribatti SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows Biomedicines angiogenesis infections SARS-CoV-2 COVID-19 intussusceptive microvascular growth |
title | SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows |
title_full | SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows |
title_fullStr | SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows |
title_full_unstemmed | SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows |
title_short | SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows |
title_sort | sars cov 2 and endothelial cells vascular changes intussusceptive microvascular growth and novel therapeutic windows |
topic | angiogenesis infections SARS-CoV-2 COVID-19 intussusceptive microvascular growth |
url | https://www.mdpi.com/2227-9059/10/9/2242 |
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