PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCER
Purpose of the study. Solving the problem of searching for prognostic factors of metastatic lesion of regional lymph nodes among the morphological and molecular characteristics of the primary breast tumor will bring modern oncology closer to finding the optimal model for individualizing diagnosis an...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2017-06-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/537 |
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| author | A. Kh. Ismagilov N. G. Asnina I. P. Moshurov G. A. Azarov |
| author_facet | A. Kh. Ismagilov N. G. Asnina I. P. Moshurov G. A. Azarov |
| author_sort | A. Kh. Ismagilov |
| collection | DOAJ |
| description | Purpose of the study. Solving the problem of searching for prognostic factors of metastatic lesion of regional lymph nodes among the morphological and molecular characteristics of the primary breast tumor will bring modern oncology closer to finding the optimal model for individualizing diagnosis and treatment of breast cancer.Materials and methods. The statistical analysis of clinical data and morphological factors obtained in the oncology department of the breast pathology of the Voronezh regional clinical oncological dispensary during a comprehensive study involving 223 patients was carried out. Only the stages I T1N0M0 and IIa T2N0M0 were taken into account.Results and discussion. The study found that patients with a lack of metastases are characterized by a relatively smaller average tumor size (20.43 ± 9.28 mm) than in patients with metastases (27.43 ± 12.4 mm), with 25 % of them having Size ≤10 mm, 50 % – from 10 to 34 mm and 25 % – ≥ 34 mm. The difference in groups on the basis of “age” is absent. A statistical relationship (p < 0.05) between the biological tumor subtype and its histological diagnosis, between the biological tumor subtype and histological diagnosis and the absence / presence of metastases in the lymph nodes (p <0.0001) was established.Conclusions. Thus, it was established that the histological and morphological study of the primary tumor provides the necessary information not only to determine its sensitivity to different types of systemic treatment and the choice of therapeutic tactics, but also to solve the problem of predicting the metastatic lesion of regional lymph nodes in breast cancer patients. |
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| id | doaj.art-461f5bb099e94d42964f8d75e2710591 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2025-03-14T08:25:53Z |
| publishDate | 2017-06-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-461f5bb099e94d42964f8d75e27105912025-03-02T13:05:34ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272017-06-01132131910.17650/1994-4098-2017-13-2-13-19532PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCERA. Kh. Ismagilov0N. G. Asnina1I. P. Moshurov2G. A. Azarov3Kazan State Medical Academy, Ministry of Health of RussiaVoronezh state University of Ministry of Education and Science of RussiaVoronezh Regional Clinical Oncology DispensaryVoronezh Regional Clinical Oncology DispensaryPurpose of the study. Solving the problem of searching for prognostic factors of metastatic lesion of regional lymph nodes among the morphological and molecular characteristics of the primary breast tumor will bring modern oncology closer to finding the optimal model for individualizing diagnosis and treatment of breast cancer.Materials and methods. The statistical analysis of clinical data and morphological factors obtained in the oncology department of the breast pathology of the Voronezh regional clinical oncological dispensary during a comprehensive study involving 223 patients was carried out. Only the stages I T1N0M0 and IIa T2N0M0 were taken into account.Results and discussion. The study found that patients with a lack of metastases are characterized by a relatively smaller average tumor size (20.43 ± 9.28 mm) than in patients with metastases (27.43 ± 12.4 mm), with 25 % of them having Size ≤10 mm, 50 % – from 10 to 34 mm and 25 % – ≥ 34 mm. The difference in groups on the basis of “age” is absent. A statistical relationship (p < 0.05) between the biological tumor subtype and its histological diagnosis, between the biological tumor subtype and histological diagnosis and the absence / presence of metastases in the lymph nodes (p <0.0001) was established.Conclusions. Thus, it was established that the histological and morphological study of the primary tumor provides the necessary information not only to determine its sensitivity to different types of systemic treatment and the choice of therapeutic tactics, but also to solve the problem of predicting the metastatic lesion of regional lymph nodes in breast cancer patients.https://ojrs.abvpress.ru/ojrs/article/view/537breast cancerregional lymph nodes |
| spellingShingle | A. Kh. Ismagilov N. G. Asnina I. P. Moshurov G. A. Azarov PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCER Опухоли женской репродуктивной системы breast cancer regional lymph nodes |
| title | PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCER |
| title_full | PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCER |
| title_fullStr | PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCER |
| title_full_unstemmed | PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCER |
| title_short | PREDICTION OF METASTATIC DAMAGE OF REGIONAL LYMPHATIC NODES IN PATIENTS WITH BREAST CANCER |
| title_sort | prediction of metastatic damage of regional lymphatic nodes in patients with breast cancer |
| topic | breast cancer regional lymph nodes |
| url | https://ojrs.abvpress.ru/ojrs/article/view/537 |
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