Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers
Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/20/4626 |
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| author | Wenji Zhang Yingyi Lian Qiuhua Li Lingli Sun Ruohong Chen Xingfei Lai Zhaoxiang Lai Erdong Yuan Shili Sun |
| author_facet | Wenji Zhang Yingyi Lian Qiuhua Li Lingli Sun Ruohong Chen Xingfei Lai Zhaoxiang Lai Erdong Yuan Shili Sun |
| author_sort | Wenji Zhang |
| collection | DOAJ |
| description | Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the anti-ulcer functions and mechanisms, and also the bioavailability, efficacy, and safety, of flavonoid monomers in the gastrointestinal tract. Flavonoids exerted cytoprotective and rehabilitative effects by not only strengthening defense factors, such as mucus and prostaglandins, but also protecting against potentially harmful factors via their antioxidative, anti-inflammatory, and antibacterial activities. Although controlled clinical studies are limited at present, flavonoids have shown a promising preventable and therapeutic potential in peptic ulcers. |
| first_indexed | 2024-03-10T15:43:18Z |
| format | Article |
| id | doaj.art-46236f90d40b44069f8c0193832e9143 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:43:18Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-46236f90d40b44069f8c0193832e91432023-11-20T16:39:47ZengMDPI AGMolecules1420-30492020-10-012520462610.3390/molecules25204626Preventative and Therapeutic Potential of Flavonoids in Peptic UlcersWenji Zhang0Yingyi Lian1Qiuhua Li2Lingli Sun3Ruohong Chen4Xingfei Lai5Zhaoxiang Lai6Erdong Yuan7Shili Sun8Guangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Tea Research Institute, Guangzhou 510640, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaGuangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Tea Research Institute, Guangzhou 510640, ChinaGuangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Tea Research Institute, Guangzhou 510640, ChinaGuangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Tea Research Institute, Guangzhou 510640, ChinaGuangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Tea Research Institute, Guangzhou 510640, ChinaGuangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Tea Research Institute, Guangzhou 510640, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaGuangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Tea Research Institute, Guangzhou 510640, ChinaPeptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the anti-ulcer functions and mechanisms, and also the bioavailability, efficacy, and safety, of flavonoid monomers in the gastrointestinal tract. Flavonoids exerted cytoprotective and rehabilitative effects by not only strengthening defense factors, such as mucus and prostaglandins, but also protecting against potentially harmful factors via their antioxidative, anti-inflammatory, and antibacterial activities. Although controlled clinical studies are limited at present, flavonoids have shown a promising preventable and therapeutic potential in peptic ulcers.https://www.mdpi.com/1420-3049/25/20/4626flavonoidspeptic ulcergastroprotective effectsantioxidationanti- inflammationantibacterial |
| spellingShingle | Wenji Zhang Yingyi Lian Qiuhua Li Lingli Sun Ruohong Chen Xingfei Lai Zhaoxiang Lai Erdong Yuan Shili Sun Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers Molecules flavonoids peptic ulcer gastroprotective effects antioxidation anti- inflammation antibacterial |
| title | Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers |
| title_full | Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers |
| title_fullStr | Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers |
| title_full_unstemmed | Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers |
| title_short | Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers |
| title_sort | preventative and therapeutic potential of flavonoids in peptic ulcers |
| topic | flavonoids peptic ulcer gastroprotective effects antioxidation anti- inflammation antibacterial |
| url | https://www.mdpi.com/1420-3049/25/20/4626 |
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