Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications

Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications

Enhanced GABAergic neurotransmission contributes to impairment of motor coordination and gait and of cognitive function in different pathologies, including hyperammonemia and hepatic encephalopathy. Neuroinflammation is a main contributor to enhancement of GABAergic neurotransmission through increas...

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Bibliographic Details
Main Authors: Marta Llansola, Yaiza M. Arenas, María Sancho-Alonso, Gergana Mincheva, Andrea Palomares-Rodriguez, Magnus Doverskog, Paula Izquierdo-Altarejos, Vicente Felipo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
GABA
neuroinflammation
motor incoordination
cognitive function
hyperammonemia
hepatic encephalopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1358323/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1358323/full

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