Evaluation of LL 37 Lipoprotein As Innate Immunity Marker among Sudanese Patients Cutaneous Leishmania
Background: The leishmaniasis is a group of diseases with a broad range of clinical manifestations caused by several species of parasites belonging to the genus Leishmania. LL-37/hCAP18, the only cathelicidin in human, is expressed as an 18-kDa preproprotein. The most prominent function of cathelici...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Knowledge E
2019-09-01
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| Series: | Sudan Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/sjms.v14i3.5208 |
| _version_ | 1830139626422009856 |
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| author | Ayat H. Bakr Abugroun E. A. AbdElkarim A. Abdrabo Omeyma A. Mohamed Mokhtar M. A. GadAllah Modawe |
| author_facet | Ayat H. Bakr Abugroun E. A. AbdElkarim A. Abdrabo Omeyma A. Mohamed Mokhtar M. A. GadAllah Modawe |
| author_sort | Ayat H. Bakr |
| collection | DOAJ |
| description | Background: The leishmaniasis is a group of diseases with a broad range of clinical manifestations caused by several species of parasites belonging to the genus Leishmania. LL-37/hCAP18, the only cathelicidin in human, is expressed as an 18-kDa preproprotein. The most prominent function of cathelicidin is their ability to inhibit propagation of a diverse range of microorganisms, which occurs at a micromolar range.
Objective: The study was aimed to evaluate the LL37 plasma level in Leishmania Sudanese patients.
Methods: In a case-control study, 300 subjects were enrolled (200 as case and 100 controls); 5 ml venous blood was collected in EDTA container, then plasma was obtained and stored frozen at –80°C. LL 37 was estimated using competitive ELISA. The data were analyzed using SPSS version 21.
Results: The results revealed that 115 (57%) of Leishimania patients were male and 85 (43%) were female. Plasma LL 37 level was significantly increased in Leishmania patients (1.30
±
0.71) compared to the control (0.21
±
0.20) with (p-value 0.000).
Conclusion: Leishmania patients had higher levels of plasma LL37, suggesting effective antimicrobial immunity process enhancing healing of cutaneous leishmaniasis. |
| first_indexed | 2024-12-17T08:47:50Z |
| format | Article |
| id | doaj.art-46267d8345a143dab7c122a842f124a7 |
| institution | Directory Open Access Journal |
| issn | 1858-5051 |
| language | English |
| last_indexed | 2024-12-17T08:47:50Z |
| publishDate | 2019-09-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj.art-46267d8345a143dab7c122a842f124a72022-12-21T21:56:10ZengKnowledge ESudan Journal of Medical Sciences1858-50512019-09-01141610.18502/sjms.v14i3.5208sjms.v14i3.5208Evaluation of LL 37 Lipoprotein As Innate Immunity Marker among Sudanese Patients Cutaneous LeishmaniaAyat H. Bakr0Abugroun E. A.1AbdElkarim A. Abdrabo2Omeyma A. Mohamed3Mokhtar M. A.4GadAllah Modawe5 Omdurman Islamic university, Faculty of Medicine, Department of Biochemistry, Omdurman, Sudan Omdurman Islamic university, Faculty of Medicine, Department of Biochemistry, Omdurman, Sudan Omdurman Islamic university, Faculty of Medicine, Department of Biochemistry, Omdurman, Sudan Omdurman Islamic university, Faculty of Medicine, Department of Biochemistry, Omdurman, Sudan Omdurman Islamic university, Faculty of Medicine, Department of Biochemistry, Omdurman, Sudan Omdurman Islamic university, Faculty of Medicine, Department of Biochemistry, Omdurman, SudanBackground: The leishmaniasis is a group of diseases with a broad range of clinical manifestations caused by several species of parasites belonging to the genus Leishmania. LL-37/hCAP18, the only cathelicidin in human, is expressed as an 18-kDa preproprotein. The most prominent function of cathelicidin is their ability to inhibit propagation of a diverse range of microorganisms, which occurs at a micromolar range. Objective: The study was aimed to evaluate the LL37 plasma level in Leishmania Sudanese patients. Methods: In a case-control study, 300 subjects were enrolled (200 as case and 100 controls); 5 ml venous blood was collected in EDTA container, then plasma was obtained and stored frozen at –80°C. LL 37 was estimated using competitive ELISA. The data were analyzed using SPSS version 21. Results: The results revealed that 115 (57%) of Leishimania patients were male and 85 (43%) were female. Plasma LL 37 level was significantly increased in Leishmania patients (1.30 ± 0.71) compared to the control (0.21 ± 0.20) with (p-value 0.000). Conclusion: Leishmania patients had higher levels of plasma LL37, suggesting effective antimicrobial immunity process enhancing healing of cutaneous leishmaniasis.https://doi.org/10.18502/sjms.v14i3.5208cathelicidin, LL37, innate immunity, Leishmania, Sudan |
| spellingShingle | Ayat H. Bakr Abugroun E. A. AbdElkarim A. Abdrabo Omeyma A. Mohamed Mokhtar M. A. GadAllah Modawe Evaluation of LL 37 Lipoprotein As Innate Immunity Marker among Sudanese Patients Cutaneous Leishmania Sudan Journal of Medical Sciences cathelicidin, LL37, innate immunity, Leishmania, Sudan |
| title | Evaluation of LL 37 Lipoprotein As Innate Immunity Marker among Sudanese Patients Cutaneous Leishmania |
| title_full | Evaluation of LL 37 Lipoprotein As Innate Immunity Marker among Sudanese Patients Cutaneous Leishmania |
| title_fullStr | Evaluation of LL 37 Lipoprotein As Innate Immunity Marker among Sudanese Patients Cutaneous Leishmania |
| title_full_unstemmed | Evaluation of LL 37 Lipoprotein As Innate Immunity Marker among Sudanese Patients Cutaneous Leishmania |
| title_short | Evaluation of LL 37 Lipoprotein As Innate Immunity Marker among Sudanese Patients Cutaneous Leishmania |
| title_sort | evaluation of ll 37 lipoprotein as innate immunity marker among sudanese patients cutaneous leishmania |
| topic | cathelicidin, LL37, innate immunity, Leishmania, Sudan |
| url | https://doi.org/10.18502/sjms.v14i3.5208 |
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