A threonyl-tRNA synthetase-mediated translation initiation machinery
The initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate the translation of a specific set of mRNAs.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09086-0 |
| _version_ | 1818855770862649344 |
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| author | Seung Jae Jeong Shinhye Park Loi T. Nguyen Jungwon Hwang Eun-Young Lee Hoi-Khoanh Giong Jeong-Soo Lee Ina Yoon Ji-Hyun Lee Jong Hyun Kim Hoi Kyoung Kim Doyeun Kim Won Suk Yang Seon-Young Kim Chan Yong Lee Kweon Yu Nahum Sonenberg Myung Hee Kim Sunghoon Kim |
| author_facet | Seung Jae Jeong Shinhye Park Loi T. Nguyen Jungwon Hwang Eun-Young Lee Hoi-Khoanh Giong Jeong-Soo Lee Ina Yoon Ji-Hyun Lee Jong Hyun Kim Hoi Kyoung Kim Doyeun Kim Won Suk Yang Seon-Young Kim Chan Yong Lee Kweon Yu Nahum Sonenberg Myung Hee Kim Sunghoon Kim |
| author_sort | Seung Jae Jeong |
| collection | DOAJ |
| description | The initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate the translation of a specific set of mRNAs. |
| first_indexed | 2024-12-19T08:13:53Z |
| format | Article |
| id | doaj.art-4626adc229bd48dc902ff7c0880575dc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:13:53Z |
| publishDate | 2019-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4626adc229bd48dc902ff7c0880575dc2022-12-21T20:29:32ZengNature PortfolioNature Communications2041-17232019-03-0110111510.1038/s41467-019-09086-0A threonyl-tRNA synthetase-mediated translation initiation machinerySeung Jae Jeong0Shinhye Park1Loi T. Nguyen2Jungwon Hwang3Eun-Young Lee4Hoi-Khoanh Giong5Jeong-Soo Lee6Ina Yoon7Ji-Hyun Lee8Jong Hyun Kim9Hoi Kyoung Kim10Doyeun Kim11Won Suk Yang12Seon-Young Kim13Chan Yong Lee14Kweon Yu15Nahum Sonenberg16Myung Hee Kim17Sunghoon Kim18Medicinal Bioconvergence Research Center, Seoul National UniversityInfection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)Disease Target Structure Research Center, KRIBBDisease Target Structure Research Center, KRIBBMedicinal Bioconvergence Research Center, Seoul National UniversityMedicinal Bioconvergence Research Center, Seoul National UniversityMedicinal Bioconvergence Research Center, Seoul National UniversityMedicinal Bioconvergence Research Center, Seoul National UniversityMedicinal Bioconvergence Research Center, Seoul National UniversityMedicinal Bioconvergence Research Center, Seoul National UniversityKRIBB School of Bioscience, Korea University of Science and TechnologyDepartment of Biochemistry, Chungnam National UniversityDisease Target Structure Research Center, KRIBBDepartment of Biochemistry, McGill University, MontrealInfection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)Medicinal Bioconvergence Research Center, Seoul National UniversityThe initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate the translation of a specific set of mRNAs.https://doi.org/10.1038/s41467-019-09086-0 |
| spellingShingle | Seung Jae Jeong Shinhye Park Loi T. Nguyen Jungwon Hwang Eun-Young Lee Hoi-Khoanh Giong Jeong-Soo Lee Ina Yoon Ji-Hyun Lee Jong Hyun Kim Hoi Kyoung Kim Doyeun Kim Won Suk Yang Seon-Young Kim Chan Yong Lee Kweon Yu Nahum Sonenberg Myung Hee Kim Sunghoon Kim A threonyl-tRNA synthetase-mediated translation initiation machinery Nature Communications |
| title | A threonyl-tRNA synthetase-mediated translation initiation machinery |
| title_full | A threonyl-tRNA synthetase-mediated translation initiation machinery |
| title_fullStr | A threonyl-tRNA synthetase-mediated translation initiation machinery |
| title_full_unstemmed | A threonyl-tRNA synthetase-mediated translation initiation machinery |
| title_short | A threonyl-tRNA synthetase-mediated translation initiation machinery |
| title_sort | threonyl trna synthetase mediated translation initiation machinery |
| url | https://doi.org/10.1038/s41467-019-09086-0 |
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