Immunohistochemistry in Ovarian Malignancies: A Comparative Study in Two Different Time Eras
Background: To assess role of immunohistochemistry in identifying primary and secondary ovarian malignancies. Methods: In this descriptive cross sectional study 65 cases of ovarian malignancies diagnosed during the year 2001, with a limited immunohistochemistry support were included. An equal number...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2013-12-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/458 |
| _version_ | 1818139757480247296 |
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| author | Usman Hassan |
| author_facet | Usman Hassan |
| author_sort | Usman Hassan |
| collection | DOAJ |
| description | Background: To assess role of immunohistochemistry in identifying primary and secondary ovarian malignancies. Methods: In this descriptive cross sectional study 65 cases of ovarian malignancies diagnosed during the year 2001, with a limited immunohistochemistry support were included. An equal number of cases (65 cases) diagnosed during the year 2012, with an extended immunochemistry support, were used for the comparison. Immunostains used in these cases were CK, CK7, CK20, Cdx2, PLAP, WT1, inhibin, Calretenin, Melan A, CD99, GCDFP15, Mammoglobin LCA, CEA, AFP, CD30 and CD10. Results: The frequency of metastatic carcinoma has changed tremendously being 3% in 2001 and 35.4% in 2012. The frequencies of other malignancies in 2001 in descending order of frequency were surface epithelial tumour (74.2%), germ cell tumours (16.2%), sex cord stromal tumours (1.5%) and others (3%). In 2012, apart from metastatic carcinoma, the frequency in descending order of frequency was surface epithelial tumours (35.4%), germ cell tumours (18.5%), sex cord stromal tumours (16.2%), and others (4.6%). There was not much difference in median ages (42.74 +15.4 and 39.54 + 15.8) Conclusion: IHC has helped in identifying primary and secondary ovarian malignancies. |
| first_indexed | 2024-12-11T10:33:10Z |
| format | Article |
| id | doaj.art-4626ca7696574d3e9b28e7d9d9c66e21 |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-12-11T10:33:10Z |
| publishDate | 2013-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-4626ca7696574d3e9b28e7d9d9c66e212022-12-22T01:10:50ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702013-12-01172Immunohistochemistry in Ovarian Malignancies: A Comparative Study in Two Different Time ErasUsman Hassan0Department of Pathology, Shaukat Khanum Memorial Cancer Hospital, and Research Centre,LahoreBackground: To assess role of immunohistochemistry in identifying primary and secondary ovarian malignancies. Methods: In this descriptive cross sectional study 65 cases of ovarian malignancies diagnosed during the year 2001, with a limited immunohistochemistry support were included. An equal number of cases (65 cases) diagnosed during the year 2012, with an extended immunochemistry support, were used for the comparison. Immunostains used in these cases were CK, CK7, CK20, Cdx2, PLAP, WT1, inhibin, Calretenin, Melan A, CD99, GCDFP15, Mammoglobin LCA, CEA, AFP, CD30 and CD10. Results: The frequency of metastatic carcinoma has changed tremendously being 3% in 2001 and 35.4% in 2012. The frequencies of other malignancies in 2001 in descending order of frequency were surface epithelial tumour (74.2%), germ cell tumours (16.2%), sex cord stromal tumours (1.5%) and others (3%). In 2012, apart from metastatic carcinoma, the frequency in descending order of frequency was surface epithelial tumours (35.4%), germ cell tumours (18.5%), sex cord stromal tumours (16.2%), and others (4.6%). There was not much difference in median ages (42.74 +15.4 and 39.54 + 15.8) Conclusion: IHC has helped in identifying primary and secondary ovarian malignancies.https://www.journalrmc.com/index.php/JRMC/article/view/458Ovarian malignancyimmunohistochemistry Introduction |
| spellingShingle | Usman Hassan Immunohistochemistry in Ovarian Malignancies: A Comparative Study in Two Different Time Eras Journal of Rawalpindi Medical College Ovarian malignancy immunohistochemistry Introduction |
| title | Immunohistochemistry in Ovarian Malignancies: A Comparative Study in Two Different Time Eras |
| title_full | Immunohistochemistry in Ovarian Malignancies: A Comparative Study in Two Different Time Eras |
| title_fullStr | Immunohistochemistry in Ovarian Malignancies: A Comparative Study in Two Different Time Eras |
| title_full_unstemmed | Immunohistochemistry in Ovarian Malignancies: A Comparative Study in Two Different Time Eras |
| title_short | Immunohistochemistry in Ovarian Malignancies: A Comparative Study in Two Different Time Eras |
| title_sort | immunohistochemistry in ovarian malignancies a comparative study in two different time eras |
| topic | Ovarian malignancy immunohistochemistry Introduction |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/458 |
| work_keys_str_mv | AT usmanhassan immunohistochemistryinovarianmalignanciesacomparativestudyintwodifferenttimeeras |