Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant <i>Candida</i> sp.
Clinical isolates of <i>Candida</i> yeast are the most common cause of opportunistic fungal infections resistant to certain antifungal drugs. Therefore, it is necessary to detect more effective antifungal agents that would be successful in overcoming such infections. Among them are some...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/6/655 |
| _version_ | 1797531912471838720 |
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| author | Anna Herman Andrzej Przemysław Herman |
| author_facet | Anna Herman Andrzej Przemysław Herman |
| author_sort | Anna Herman |
| collection | DOAJ |
| description | Clinical isolates of <i>Candida</i> yeast are the most common cause of opportunistic fungal infections resistant to certain antifungal drugs. Therefore, it is necessary to detect more effective antifungal agents that would be successful in overcoming such infections. Among them are some herbal products and their active constituents.The purpose of this review is to summarize the current state of knowledge onherbal products and their active constituents havingantifungal activity against drug-resistant <i>Candida</i> sp. used alone and in combination with antifungal drugs.The possible mechanisms of their action on drug-resistant <i>Candida</i> sp. including (1) inhibition of budding yeast transformation into hyphae; (2) inhibition of biofilm formation; (3) inhibition of cell wall or cytoplasmic membrane biosynthesis; (4) ROS production; and (5) over-expression of membrane transporters will be also described. |
| first_indexed | 2024-03-10T10:51:32Z |
| format | Article |
| id | doaj.art-4627355274274892bdb0e7bcb8022a22 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T10:51:32Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-4627355274274892bdb0e7bcb8022a222023-11-21T22:10:16ZengMDPI AGAntibiotics2079-63822021-05-0110665510.3390/antibiotics10060655Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant <i>Candida</i> sp.Anna Herman0Andrzej Przemysław Herman1Faculty of Health Sciences, Warsaw School of Engineering and Health, Bitwy Warszawskiej 1920 18 Street, 02-366 Warsaw, PolandDepartment of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, PolandClinical isolates of <i>Candida</i> yeast are the most common cause of opportunistic fungal infections resistant to certain antifungal drugs. Therefore, it is necessary to detect more effective antifungal agents that would be successful in overcoming such infections. Among them are some herbal products and their active constituents.The purpose of this review is to summarize the current state of knowledge onherbal products and their active constituents havingantifungal activity against drug-resistant <i>Candida</i> sp. used alone and in combination with antifungal drugs.The possible mechanisms of their action on drug-resistant <i>Candida</i> sp. including (1) inhibition of budding yeast transformation into hyphae; (2) inhibition of biofilm formation; (3) inhibition of cell wall or cytoplasmic membrane biosynthesis; (4) ROS production; and (5) over-expression of membrane transporters will be also described.https://www.mdpi.com/2079-6382/10/6/655herbalproductsherbal active constituentsdrug-resistant <i>Candida</i> sp.antifungal drug |
| spellingShingle | Anna Herman Andrzej Przemysław Herman Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant <i>Candida</i> sp. Antibiotics herbalproducts herbal active constituents drug-resistant <i>Candida</i> sp. antifungal drug |
| title | Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant <i>Candida</i> sp. |
| title_full | Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant <i>Candida</i> sp. |
| title_fullStr | Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant <i>Candida</i> sp. |
| title_full_unstemmed | Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant <i>Candida</i> sp. |
| title_short | Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant <i>Candida</i> sp. |
| title_sort | herbal products and their active constituents used alone and in combination with antifungal drugs against drug resistant i candida i sp |
| topic | herbalproducts herbal active constituents drug-resistant <i>Candida</i> sp. antifungal drug |
| url | https://www.mdpi.com/2079-6382/10/6/655 |
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