Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.
Acute myeloid leukemia (AML), caused by abnormal proliferation and accumulation of hematopoietic progenitor cells, is one of the most common malignancies in adults. We reported here DYRK1A expression level was reduced in the bone marrow of adult AML patients, comparing to normal controls. Overexpres...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4047119?pdf=render |
| _version_ | 1819088109027983360 |
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| author | Qiang Liu Na Liu Shaolei Zang Heng Liu Pin Wang Chunyan Ji Xiulian Sun |
| author_facet | Qiang Liu Na Liu Shaolei Zang Heng Liu Pin Wang Chunyan Ji Xiulian Sun |
| author_sort | Qiang Liu |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML), caused by abnormal proliferation and accumulation of hematopoietic progenitor cells, is one of the most common malignancies in adults. We reported here DYRK1A expression level was reduced in the bone marrow of adult AML patients, comparing to normal controls. Overexpression of DYRK1A inhibited the proliferation of AML cell lines by increasing the proportion of cells undergoing G0/G1 phase. We reasoned that the proliferative inhibition was due to downregulation of c-Myc by DYRK1A, through mediating its degradation. Moreover, overexpression of c-Myc markedly reversed AML cell growth inhibition induced by DYRK1A. DYRK1A also had significantly lower expression in relapsed/refractory AML patients, comparing to newly-diagnosed AML patients, which indicated the role of DYRK1A in chemoresistance of AML. Our study provided functional evidences for DYRK1A as a potential tumor suppressor in AML. |
| first_indexed | 2024-12-21T21:46:48Z |
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| id | doaj.art-4629972f117b42278a546a93eb117e5a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T21:46:48Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-4629972f117b42278a546a93eb117e5a2022-12-21T18:49:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9885310.1371/journal.pone.0098853Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.Qiang LiuNa LiuShaolei ZangHeng LiuPin WangChunyan JiXiulian SunAcute myeloid leukemia (AML), caused by abnormal proliferation and accumulation of hematopoietic progenitor cells, is one of the most common malignancies in adults. We reported here DYRK1A expression level was reduced in the bone marrow of adult AML patients, comparing to normal controls. Overexpression of DYRK1A inhibited the proliferation of AML cell lines by increasing the proportion of cells undergoing G0/G1 phase. We reasoned that the proliferative inhibition was due to downregulation of c-Myc by DYRK1A, through mediating its degradation. Moreover, overexpression of c-Myc markedly reversed AML cell growth inhibition induced by DYRK1A. DYRK1A also had significantly lower expression in relapsed/refractory AML patients, comparing to newly-diagnosed AML patients, which indicated the role of DYRK1A in chemoresistance of AML. Our study provided functional evidences for DYRK1A as a potential tumor suppressor in AML.http://europepmc.org/articles/PMC4047119?pdf=render |
| spellingShingle | Qiang Liu Na Liu Shaolei Zang Heng Liu Pin Wang Chunyan Ji Xiulian Sun Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc. PLoS ONE |
| title | Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc. |
| title_full | Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc. |
| title_fullStr | Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc. |
| title_full_unstemmed | Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc. |
| title_short | Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc. |
| title_sort | tumor suppressor dyrk1a effects on proliferation and chemoresistance of aml cells by downregulating c myc |
| url | http://europepmc.org/articles/PMC4047119?pdf=render |
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