Population structure of Staphylococcus aureus from remote African Babongo Pygmies.
BACKGROUND: Pandemic community-acquired methicillin-resistant Staphylococcus aureus isolates (CA-MRSA) predominantly encode the Panton-Valentine leukocidin (PVL), which can be associated with severe infections. Reports from non-indigenous Sub-Saharan African populations revealed a high prevalence of...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC3091839?pdf=render |
| _version_ | 1818543248847667200 |
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| author | Frieder Schaumburg Robin Köck Alexander W Friedrich Solange Soulanoudjingar Ulysse Ateba Ngoa Christof von Eiff Saadou Issifou Peter G Kremsner Mathias Herrmann Georg Peters Karsten Becker |
| author_facet | Frieder Schaumburg Robin Köck Alexander W Friedrich Solange Soulanoudjingar Ulysse Ateba Ngoa Christof von Eiff Saadou Issifou Peter G Kremsner Mathias Herrmann Georg Peters Karsten Becker |
| author_sort | Frieder Schaumburg |
| collection | DOAJ |
| description | BACKGROUND: Pandemic community-acquired methicillin-resistant Staphylococcus aureus isolates (CA-MRSA) predominantly encode the Panton-Valentine leukocidin (PVL), which can be associated with severe infections. Reports from non-indigenous Sub-Saharan African populations revealed a high prevalence of PVL-positive isolates. The objective of our study was to investigate the S. aureus carriage among a remote indigenous African population and to determine the molecular characteristics of the isolates, particularly those that were PVL-positive. METHODOLOGY/PRINCIPAL FINDINGS: Nasal S. aureus carriage and risk factors of colonization were systematically assessed in remote Gabonese Babongo Pygmies. Susceptibility to antibiotics, possession of toxin-encoding genes (i.e., PVL, enterotoxins, and exfoliative toxins), S. aureus protein A (spa) types and multi-locus sequence types (MLST) were determined for each isolate. The carriage rate was 33%. No MRSA was detected, 61.8% of the isolates were susceptible to penicillin. Genes encoding PVL (55.9%), enterotoxin B (20.6%), exfoliative toxin D (11.7%) and the epidermal cell differentiation inhibitor B (11.7%) were highly prevalent. Thirteen spa types were detected and were associated with 10 STs predominated by ST15, ST30, ST72, ST80, and ST88. CONCLUSIONS: The high prevalence of PVL-positive isolates among Babongo Pygmies demands our attention as PVL can be associated with necrotinzing infection and may increase the risk of severe infections in remote Pygmy populations. Many S. aureus isolates from Babongo Pygmies and pandemic CA-MRSA-clones have a common genetic background. Surveillance is needed to control the development of resistance to antibiotic drugs and to assess the impact of the high prevalence of PVL in indigenous populations. |
| first_indexed | 2024-12-11T22:32:52Z |
| format | Article |
| id | doaj.art-462a0376e2c64cd1bf72e93cced00119 |
| institution | Directory Open Access Journal |
| issn | 1935-2735 |
| language | English |
| last_indexed | 2024-12-11T22:32:52Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-462a0376e2c64cd1bf72e93cced001192022-12-22T00:48:05ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27352011-01-0155e115010.1371/journal.pntd.0001150Population structure of Staphylococcus aureus from remote African Babongo Pygmies.Frieder SchaumburgRobin KöckAlexander W FriedrichSolange SoulanoudjingarUlysse Ateba NgoaChristof von EiffSaadou IssifouPeter G KremsnerMathias HerrmannGeorg PetersKarsten BeckerBACKGROUND: Pandemic community-acquired methicillin-resistant Staphylococcus aureus isolates (CA-MRSA) predominantly encode the Panton-Valentine leukocidin (PVL), which can be associated with severe infections. Reports from non-indigenous Sub-Saharan African populations revealed a high prevalence of PVL-positive isolates. The objective of our study was to investigate the S. aureus carriage among a remote indigenous African population and to determine the molecular characteristics of the isolates, particularly those that were PVL-positive. METHODOLOGY/PRINCIPAL FINDINGS: Nasal S. aureus carriage and risk factors of colonization were systematically assessed in remote Gabonese Babongo Pygmies. Susceptibility to antibiotics, possession of toxin-encoding genes (i.e., PVL, enterotoxins, and exfoliative toxins), S. aureus protein A (spa) types and multi-locus sequence types (MLST) were determined for each isolate. The carriage rate was 33%. No MRSA was detected, 61.8% of the isolates were susceptible to penicillin. Genes encoding PVL (55.9%), enterotoxin B (20.6%), exfoliative toxin D (11.7%) and the epidermal cell differentiation inhibitor B (11.7%) were highly prevalent. Thirteen spa types were detected and were associated with 10 STs predominated by ST15, ST30, ST72, ST80, and ST88. CONCLUSIONS: The high prevalence of PVL-positive isolates among Babongo Pygmies demands our attention as PVL can be associated with necrotinzing infection and may increase the risk of severe infections in remote Pygmy populations. Many S. aureus isolates from Babongo Pygmies and pandemic CA-MRSA-clones have a common genetic background. Surveillance is needed to control the development of resistance to antibiotic drugs and to assess the impact of the high prevalence of PVL in indigenous populations.http://europepmc.org/articles/PMC3091839?pdf=render |
| spellingShingle | Frieder Schaumburg Robin Köck Alexander W Friedrich Solange Soulanoudjingar Ulysse Ateba Ngoa Christof von Eiff Saadou Issifou Peter G Kremsner Mathias Herrmann Georg Peters Karsten Becker Population structure of Staphylococcus aureus from remote African Babongo Pygmies. PLoS Neglected Tropical Diseases |
| title | Population structure of Staphylococcus aureus from remote African Babongo Pygmies. |
| title_full | Population structure of Staphylococcus aureus from remote African Babongo Pygmies. |
| title_fullStr | Population structure of Staphylococcus aureus from remote African Babongo Pygmies. |
| title_full_unstemmed | Population structure of Staphylococcus aureus from remote African Babongo Pygmies. |
| title_short | Population structure of Staphylococcus aureus from remote African Babongo Pygmies. |
| title_sort | population structure of staphylococcus aureus from remote african babongo pygmies |
| url | http://europepmc.org/articles/PMC3091839?pdf=render |
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