Therapeutic Approaches to Vulvar Cancer: A Review of Literature
Objective: Vulvar cancer is a rare gynecological cancer that mainly affects postmenopausal women. The aim of this review is to analyze the most recent data available in the literature on the clinical and therapeutic approach to vulvar carcinoma. Mechanism: Studies available in the literature on the...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2023-07-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/7/10.31083/j.ceog5007143 |
| _version_ | 1797768955198177280 |
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| author | Tullio Golia D'Augè Ilaria Firulli Giorgia Di Bartolomeo Ilaria Cuccu Camilla Turetta Angelo Trezza Giorgio Bogani Innocenza Palaia Giorgia Perniola Federica Tomao Ludovico Muzii Violante Di Donato Ottavia D'Oria Andrea Giannini |
| author_facet | Tullio Golia D'Augè Ilaria Firulli Giorgia Di Bartolomeo Ilaria Cuccu Camilla Turetta Angelo Trezza Giorgio Bogani Innocenza Palaia Giorgia Perniola Federica Tomao Ludovico Muzii Violante Di Donato Ottavia D'Oria Andrea Giannini |
| author_sort | Tullio Golia D'Augè |
| collection | DOAJ |
| description | Objective: Vulvar cancer is a rare gynecological cancer that mainly affects postmenopausal women. The aim of this review is to analyze the most recent data available in the literature on the clinical and therapeutic approach to vulvar carcinoma. Mechanism: Studies available in the literature on the therapeutic management of patients with vulvar carcinoma until November 2022 have been screened. A comprehensive search was performed in the PubMed (MEDLINE), EMBASE, SCOPUS and Web of Science databases. Findings in Brief: The approach to vulvar carcinoma has deeply evolved over the years. The management of early-stage vulvar carcinomas is well established and widely shared, while that of advanced and recurrent cancers is a subject of debate. The assessment of the nodal status has changed from the past with the passage from inguinal lymphadenectomy to the removal of only the sentinel node. Conclusions: The gold standard for the management of vulvar cancer is surgery, applicable in the first instance in early-stage tumors and after neoadjuvant therapy for larger tumors. Assessment of the nodal state is crucial and the method to be used depends on the degree of suspicious of positive lymph nodes. The prognosis is good if the treatment is applicable as soon as possible. |
| first_indexed | 2024-03-12T21:01:51Z |
| format | Article |
| id | doaj.art-462a71c138ad44f3a20d52f26ab609ac |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-12T21:01:51Z |
| publishDate | 2023-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-462a71c138ad44f3a20d52f26ab609ac2023-07-31T06:06:12ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-07-0150714310.31083/j.ceog5007143S0390-6663(23)02064-XTherapeutic Approaches to Vulvar Cancer: A Review of LiteratureTullio Golia D'Augè0Ilaria Firulli1Giorgia Di Bartolomeo2Ilaria Cuccu3Camilla Turetta4Angelo Trezza5Giorgio Bogani6Innocenza Palaia7Giorgia Perniola8Federica Tomao9Ludovico Muzii10Violante Di Donato11Ottavia D'Oria12Andrea Giannini13Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyGynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Woman's and Child's Health, Obstetrics and Gynecological Unit, San Camillo-Forlanini Hospital, 00152 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyObjective: Vulvar cancer is a rare gynecological cancer that mainly affects postmenopausal women. The aim of this review is to analyze the most recent data available in the literature on the clinical and therapeutic approach to vulvar carcinoma. Mechanism: Studies available in the literature on the therapeutic management of patients with vulvar carcinoma until November 2022 have been screened. A comprehensive search was performed in the PubMed (MEDLINE), EMBASE, SCOPUS and Web of Science databases. Findings in Brief: The approach to vulvar carcinoma has deeply evolved over the years. The management of early-stage vulvar carcinomas is well established and widely shared, while that of advanced and recurrent cancers is a subject of debate. The assessment of the nodal status has changed from the past with the passage from inguinal lymphadenectomy to the removal of only the sentinel node. Conclusions: The gold standard for the management of vulvar cancer is surgery, applicable in the first instance in early-stage tumors and after neoadjuvant therapy for larger tumors. Assessment of the nodal state is crucial and the method to be used depends on the degree of suspicious of positive lymph nodes. The prognosis is good if the treatment is applicable as soon as possible.https://www.imrpress.com/journal/CEOG/50/7/10.31083/j.ceog5007143vulvar cancervulvectomynodal statusvulvar flapvulvar surgeryvulvar safe margins |
| spellingShingle | Tullio Golia D'Augè Ilaria Firulli Giorgia Di Bartolomeo Ilaria Cuccu Camilla Turetta Angelo Trezza Giorgio Bogani Innocenza Palaia Giorgia Perniola Federica Tomao Ludovico Muzii Violante Di Donato Ottavia D'Oria Andrea Giannini Therapeutic Approaches to Vulvar Cancer: A Review of Literature Clinical and Experimental Obstetrics & Gynecology vulvar cancer vulvectomy nodal status vulvar flap vulvar surgery vulvar safe margins |
| title | Therapeutic Approaches to Vulvar Cancer: A Review of Literature |
| title_full | Therapeutic Approaches to Vulvar Cancer: A Review of Literature |
| title_fullStr | Therapeutic Approaches to Vulvar Cancer: A Review of Literature |
| title_full_unstemmed | Therapeutic Approaches to Vulvar Cancer: A Review of Literature |
| title_short | Therapeutic Approaches to Vulvar Cancer: A Review of Literature |
| title_sort | therapeutic approaches to vulvar cancer a review of literature |
| topic | vulvar cancer vulvectomy nodal status vulvar flap vulvar surgery vulvar safe margins |
| url | https://www.imrpress.com/journal/CEOG/50/7/10.31083/j.ceog5007143 |
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