From 2D to 3D Cancer Cell Models—The Enigmas of Drug Delivery Research
Over the past decades, research has made impressive breakthroughs towards drug delivery systems, resulting in a wide range of multifunctional engineered nanoparticles with biomedical applications such as cancer therapy. Despite these significant advances, well-designed nanoparticles rarely reach the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/10/11/2236 |
| _version_ | 1797548174886305792 |
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| author | Indra Van Zundert Beatrice Fortuni Susana Rocha |
| author_facet | Indra Van Zundert Beatrice Fortuni Susana Rocha |
| author_sort | Indra Van Zundert |
| collection | DOAJ |
| description | Over the past decades, research has made impressive breakthroughs towards drug delivery systems, resulting in a wide range of multifunctional engineered nanoparticles with biomedical applications such as cancer therapy. Despite these significant advances, well-designed nanoparticles rarely reach the clinical stage. Promising results obtained in standard 2D cell culture systems often turn into disappointing outcomes in in vivo models. Although the overall majority of in vitro nanoparticle research is still performed on 2D monolayer cultures, more and more researchers started acknowledging the importance of using 3D cell culture systems, as better models for mimicking the in vivo tumor physiology. In this review, we provide a comprehensive overview of the 3D cancer cell models currently available. We highlight their potential as a platform for drug delivery studies and pinpoint the challenges associated with their use. We discuss in which way each 3D model mimics the in vivo tumor physiology, how they can or have been used in nanomedicine research and to what extent the results obtained so far affect the progress of nanomedicine development. It is of note that the global scientific output associated with 3D models is limited, showing that the use of these systems in nanomedicine investigation is still highly challenging. |
| first_indexed | 2024-03-10T14:55:44Z |
| format | Article |
| id | doaj.art-462b4e55f8fc458c9b053b4482754624 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T14:55:44Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-462b4e55f8fc458c9b053b44827546242023-11-20T20:34:19ZengMDPI AGNanomaterials2079-49912020-11-011011223610.3390/nano10112236From 2D to 3D Cancer Cell Models—The Enigmas of Drug Delivery ResearchIndra Van Zundert0Beatrice Fortuni1Susana Rocha2Molecular Imaging and Photonics, Chemistry Department, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, BelgiumMolecular Imaging and Photonics, Chemistry Department, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, BelgiumMolecular Imaging and Photonics, Chemistry Department, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, BelgiumOver the past decades, research has made impressive breakthroughs towards drug delivery systems, resulting in a wide range of multifunctional engineered nanoparticles with biomedical applications such as cancer therapy. Despite these significant advances, well-designed nanoparticles rarely reach the clinical stage. Promising results obtained in standard 2D cell culture systems often turn into disappointing outcomes in in vivo models. Although the overall majority of in vitro nanoparticle research is still performed on 2D monolayer cultures, more and more researchers started acknowledging the importance of using 3D cell culture systems, as better models for mimicking the in vivo tumor physiology. In this review, we provide a comprehensive overview of the 3D cancer cell models currently available. We highlight their potential as a platform for drug delivery studies and pinpoint the challenges associated with their use. We discuss in which way each 3D model mimics the in vivo tumor physiology, how they can or have been used in nanomedicine research and to what extent the results obtained so far affect the progress of nanomedicine development. It is of note that the global scientific output associated with 3D models is limited, showing that the use of these systems in nanomedicine investigation is still highly challenging.https://www.mdpi.com/2079-4991/10/11/2236nanoparticlesdrug delivery systemsspheroids3D culture systems3D cell models |
| spellingShingle | Indra Van Zundert Beatrice Fortuni Susana Rocha From 2D to 3D Cancer Cell Models—The Enigmas of Drug Delivery Research Nanomaterials nanoparticles drug delivery systems spheroids 3D culture systems 3D cell models |
| title | From 2D to 3D Cancer Cell Models—The Enigmas of Drug Delivery Research |
| title_full | From 2D to 3D Cancer Cell Models—The Enigmas of Drug Delivery Research |
| title_fullStr | From 2D to 3D Cancer Cell Models—The Enigmas of Drug Delivery Research |
| title_full_unstemmed | From 2D to 3D Cancer Cell Models—The Enigmas of Drug Delivery Research |
| title_short | From 2D to 3D Cancer Cell Models—The Enigmas of Drug Delivery Research |
| title_sort | from 2d to 3d cancer cell models the enigmas of drug delivery research |
| topic | nanoparticles drug delivery systems spheroids 3D culture systems 3D cell models |
| url | https://www.mdpi.com/2079-4991/10/11/2236 |
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