Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model
Abstract This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJC0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJC0701 aga...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Laboratory Animal Research |
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| Online Access: | http://link.springer.com/article/10.5625/lar.2018.34.1.37 |
| _version_ | 1828453818855063552 |
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| author | Song-Hee Han Sung-June Kim Young Won Yun Sang Yoon Nam Hu-Jang Lee Beom-Jun Lee |
| author_facet | Song-Hee Han Sung-June Kim Young Won Yun Sang Yoon Nam Hu-Jang Lee Beom-Jun Lee |
| author_sort | Song-Hee Han |
| collection | DOAJ |
| description | Abstract This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJC0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJC0701 against the SPL-induced memory loss animal model. The Morris water maze test, which measures hippocampus-dependent learning ability, and the Y-maze test, a short-term memory assessment test, were performed and related markers were analyzed. HLJG0701-treated groups displayed significantly reduced acetylcholinesterase activity and increased acetylcholine level compared with the SPL-administered group (SPL-G) (P<0.05). In the Y-maze test, the spontaneous alternation in al HLJC0711-treated groups was significantly increased compared with that in SPL-G (P<0.05). In the Morris water maze test, the escape latency and time spent in the target quadrant in all HLJC0701-treated groups were significantly decreased and increased, respectively, compared with those in SPL-G (P<0.05). In addition, the brain-derived neurotrophic factor level in groups treated with HLJC0701 300 and 600 mg/kg body weight was significantly increased compared with that in SPL-G (P<0.05). These results suggest that the HLJC0701 may protect against memory loss by inhibiting acetylcholinesterase activity and preventing acetylcholine deficiency. |
| first_indexed | 2024-12-11T00:12:22Z |
| format | Article |
| id | doaj.art-462e2205b5e942068fd5136c3d450022 |
| institution | Directory Open Access Journal |
| issn | 2233-7660 |
| language | English |
| last_indexed | 2024-12-11T00:12:22Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Laboratory Animal Research |
| spelling | doaj.art-462e2205b5e942068fd5136c3d4500222022-12-22T01:28:05ZengBMCLaboratory Animal Research2233-76602018-12-01341374310.5625/lar.2018.34.1.37Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse modelSong-Hee Han0Sung-June Kim1Young Won Yun2Sang Yoon Nam3Hu-Jang Lee4Beom-Jun Lee5College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National UniversityCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National UniversityCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National UniversityCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National UniversityCollege of Veterinary Medicine and Institute of Animal Medicine, Gyeongsang National UniversityCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National UniversityAbstract This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJC0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJC0701 against the SPL-induced memory loss animal model. The Morris water maze test, which measures hippocampus-dependent learning ability, and the Y-maze test, a short-term memory assessment test, were performed and related markers were analyzed. HLJG0701-treated groups displayed significantly reduced acetylcholinesterase activity and increased acetylcholine level compared with the SPL-administered group (SPL-G) (P<0.05). In the Y-maze test, the spontaneous alternation in al HLJC0711-treated groups was significantly increased compared with that in SPL-G (P<0.05). In the Morris water maze test, the escape latency and time spent in the target quadrant in all HLJC0701-treated groups were significantly decreased and increased, respectively, compared with those in SPL-G (P<0.05). In addition, the brain-derived neurotrophic factor level in groups treated with HLJC0701 300 and 600 mg/kg body weight was significantly increased compared with that in SPL-G (P<0.05). These results suggest that the HLJC0701 may protect against memory loss by inhibiting acetylcholinesterase activity and preventing acetylcholine deficiency.http://link.springer.com/article/10.5625/lar.2018.34.1.37Memory lossginsenosidesscopolamineacetylcholinemice |
| spellingShingle | Song-Hee Han Sung-June Kim Young Won Yun Sang Yoon Nam Hu-Jang Lee Beom-Jun Lee Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model Laboratory Animal Research Memory loss ginsenosides scopolamine acetylcholine mice |
| title | Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model |
| title_full | Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model |
| title_fullStr | Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model |
| title_full_unstemmed | Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model |
| title_short | Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model |
| title_sort | protective effects of cultured and fermented ginseng extracts against scopolamine induced memory loss in a mouse model |
| topic | Memory loss ginsenosides scopolamine acetylcholine mice |
| url | http://link.springer.com/article/10.5625/lar.2018.34.1.37 |
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