SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient
Objectives: Intra-host SARS-CoV-2 evolution during chronic infection in immunocompromised hosts has been suggested as being the possible trigger of the emergence of new variants. Methods: Using a deep sequencing approach, we investigated the SARS-CoV-2 intra-host genetic evolution in a patient with...
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Format: | Article |
Language: | English |
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Elsevier
2022-09-01
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Series: | International Journal of Infectious Diseases |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222003599 |
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author | Erika Giorgia Quaranta Alice Fusaro Edoardo Giussani Valeria D'Amico Maria Varotto Matteo Pagliari Maria Teresa Giordani Maira Zoppelletto Francesca Merola Antonio Antico Paola Stefanelli Calogero Terregino Isabella Monne |
author_facet | Erika Giorgia Quaranta Alice Fusaro Edoardo Giussani Valeria D'Amico Maria Varotto Matteo Pagliari Maria Teresa Giordani Maira Zoppelletto Francesca Merola Antonio Antico Paola Stefanelli Calogero Terregino Isabella Monne |
author_sort | Erika Giorgia Quaranta |
collection | DOAJ |
description | Objectives: Intra-host SARS-CoV-2 evolution during chronic infection in immunocompromised hosts has been suggested as being the possible trigger of the emergence of new variants. Methods: Using a deep sequencing approach, we investigated the SARS-CoV-2 intra-host genetic evolution in a patient with HIV over a period of 109 days. Results: Sequencing of nasopharyngeal swabs at three time points demonstrated dynamic changes in the viral population, with the emergence of 26 amino acid mutations and two deletions, 57% of them in the Spike protein. Such a combination of mutations has never been observed in other SARS-CoV-2 lineages detected so far. Conclusion: Our data confirm that persistent infection in certain immunocompromised individuals for a long time may favor the dangerous emergence of new SARS-CoV-2 variants with immune evasion properties. |
first_indexed | 2024-04-11T12:22:33Z |
format | Article |
id | doaj.art-462e382bbc8b4ee2b3ffd8e5349b5926 |
institution | Directory Open Access Journal |
issn | 1201-9712 |
language | English |
last_indexed | 2024-04-11T12:22:33Z |
publishDate | 2022-09-01 |
publisher | Elsevier |
record_format | Article |
series | International Journal of Infectious Diseases |
spelling | doaj.art-462e382bbc8b4ee2b3ffd8e5349b59262022-12-22T04:24:03ZengElsevierInternational Journal of Infectious Diseases1201-97122022-09-01122444448SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patientErika Giorgia Quaranta0Alice Fusaro1Edoardo Giussani2Valeria D'Amico3Maria Varotto4Matteo Pagliari5Maria Teresa Giordani6Maira Zoppelletto7Francesca Merola8Antonio Antico9Paola Stefanelli10Calogero Terregino11Isabella Monne12Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy; Corresponding author: Erika Giorgia Quaranta, Laboratory for Viral Genomics and Trascriptomics, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell'Università 10, 35020 Legnaro (Padova), Italy.Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, ItalyDivision of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, ItalyDivision of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, ItalyDivision of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, ItalyDivision of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, ItalyInfectious Diseases Unit, Alto Vicentino Hospital, ULSS 7 Pedemontana, Santorso, Vicenza, ItalySan Bassiano Hospital, ULSS 7 Pedemontana, Bassano del Grappa, Vicenza, ItalySan Bassiano Hospital, ULSS 7 Pedemontana, Bassano del Grappa, Vicenza, ItalySan Bassiano Hospital, ULSS 7 Pedemontana, Bassano del Grappa, Vicenza, ItalyDepartment of Infectious Diseases, Istituto Superiore di Sanità, Roma, ItalyDivision of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, ItalyDivision of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, ItalyObjectives: Intra-host SARS-CoV-2 evolution during chronic infection in immunocompromised hosts has been suggested as being the possible trigger of the emergence of new variants. Methods: Using a deep sequencing approach, we investigated the SARS-CoV-2 intra-host genetic evolution in a patient with HIV over a period of 109 days. Results: Sequencing of nasopharyngeal swabs at three time points demonstrated dynamic changes in the viral population, with the emergence of 26 amino acid mutations and two deletions, 57% of them in the Spike protein. Such a combination of mutations has never been observed in other SARS-CoV-2 lineages detected so far. Conclusion: Our data confirm that persistent infection in certain immunocompromised individuals for a long time may favor the dangerous emergence of new SARS-CoV-2 variants with immune evasion properties.http://www.sciencedirect.com/science/article/pii/S1201971222003599SARS-CoV-2Immunocompromised patientIntra-host evolutionProlonged infectionSequencing |
spellingShingle | Erika Giorgia Quaranta Alice Fusaro Edoardo Giussani Valeria D'Amico Maria Varotto Matteo Pagliari Maria Teresa Giordani Maira Zoppelletto Francesca Merola Antonio Antico Paola Stefanelli Calogero Terregino Isabella Monne SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient International Journal of Infectious Diseases SARS-CoV-2 Immunocompromised patient Intra-host evolution Prolonged infection Sequencing |
title | SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient |
title_full | SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient |
title_fullStr | SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient |
title_full_unstemmed | SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient |
title_short | SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient |
title_sort | sars cov 2 intra host evolution during prolonged infection in an immunocompromised patient |
topic | SARS-CoV-2 Immunocompromised patient Intra-host evolution Prolonged infection Sequencing |
url | http://www.sciencedirect.com/science/article/pii/S1201971222003599 |
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