Cathepsin F of is a recently evolved cysteine protease

Parasitic cysteine proteases are involved in parasite stage transition, invasion of host tissues, nutrient uptake, and immune evasion. The cysteine protease cathepsin F is the most abundant protein produced by fourth-stage larvae (L4) of the nematode Teladorsagia circumcincta , while its transcript...

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Bibliographic Details
Main Authors: Sarah Sloan, Caitlin Jenvey, Callum Cairns, Michael Stear
Format: Article
Language:English
Published: SAGE Publishing 2020-10-01
Series:Evolutionary Bioinformatics
Online Access:https://doi.org/10.1177/1176934320962521
Description
Summary:Parasitic cysteine proteases are involved in parasite stage transition, invasion of host tissues, nutrient uptake, and immune evasion. The cysteine protease cathepsin F is the most abundant protein produced by fourth-stage larvae (L4) of the nematode Teladorsagia circumcincta , while its transcript is only detectable in L4 and adults. T. circumcincta cathepsin F is a recently evolved cysteine protease that does not fall clearly into either of the cathepsin L or F subfamilies. This protein exhibits characteristics of both cathepsins F and L, and its phylogenetic relationship to its closest homologs is distant, including proteins of closely related nematodes of the same subfamily.
ISSN:1176-9343