The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular Tumors
Iulia Cristina Roca,1,* Elena Cojocaru,2 Carmen Daniela Rusu,1 Laura Mihaela Trandafir,3 Cătălina Iulia Săveanu,4 Vasile Valeriu Lupu,3,* Lăcrămioara Ionela Butnariu,5 Viorel Ţarcă,6,* Mihaela Moscal...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2024-01-01
|
| Series: | Pediatric Health, Medicine and Therapeutics |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-role-of-natural-extracts-in-the-management-of-infantile-hemangioma-peer-reviewed-fulltext-article-PHMT |
| _version_ | 1797362703840313344 |
|---|---|
| author | Roca IC Cojocaru E Rusu CD Trandafir LM Săveanu CI Lupu VV Butnariu LI Ţarcă V Moscalu M Bernic J Lupu A Ţarcă E |
| author_facet | Roca IC Cojocaru E Rusu CD Trandafir LM Săveanu CI Lupu VV Butnariu LI Ţarcă V Moscalu M Bernic J Lupu A Ţarcă E |
| author_sort | Roca IC |
| collection | DOAJ |
| description | Iulia Cristina Roca,1,* Elena Cojocaru,2 Carmen Daniela Rusu,1 Laura Mihaela Trandafir,3 Cătălina Iulia Săveanu,4 Vasile Valeriu Lupu,3,* Lăcrămioara Ionela Butnariu,5 Viorel Ţarcă,6,* Mihaela Moscalu,6 Jana Bernic,7 Ancuța Lupu,3,* Elena Ţarcă1 1Department of Surgery II, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, 700115, Romania; 2Department of Morphofunctional Sciences I – Pathology, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, 700115, Romania; 3Department of Mother and Child Medicine–Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, 700115, Romania; 4Surgical Department, Discipline of Preventive Dentistry, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, 700115, Romania; 5Department of Medical Genetics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, 700115, Romania; 6Department of Preventive Medicine and Interdisciplinarity, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, 700115, Romania; 7Discipline of Pediatric Surgery, “Nicolae Testemițanu” State University of Medicine and Pharmacy, Chisinau, Moldova*These authors contributed equally to this workCorrespondence: Carmen Daniela Rusu; Cătălina Iulia Săveanu, Tel +40765485446, Email carmen-daniela.rusu@umfiasi.ro; catalina.saveanu@umfiasi.roAbstract: Hemangiomas are vascular tumors resulting from the proliferation of endothelial-like cells; they are the most common childhood tumors, affecting approximately 5– 10% of newborns and infants. Besides hemangiomas, which are definitely benign tumors despite their overgrowth potential, there are other vascular tumors like hemangioendotheliomas, which may display intermediate characteristics between benign hemangiomas and highly malignant angiosarcomas. Standard therapy may be constricted by serious adverse effects, high cost, or traumatic influence. Diet is a major resource for health preservation, disease prevention, and treatment. The therapeutic property of edible berries, marine products, or medicinal plants have long been known and used in traditional medicine; a plant-based nutrition can prevent the development and progression of diseases associated with extensive neo-vascularization. The purpose of our review is to highlight those natural treatments that hemangioma and vascular tumor patients can receive in the future, both for their benefit and that of their families. We performed the review according to the Preferred Reporting Items for Systematic Reviews and Metanalysis Statement. We used the Web of Science, PubMed, and EMBASE engines for the study, and searched for the association of hemangioma with naturopathic treatment/plant extract/plants in published articles. We found that natural extracts from plants and fruits are cost-effective and safe treatments for hemangiomas and vascular tumors, as well as for other forms of cancer. In any case, more in vitro and in vivo studies are needed to confirm the proposed signaling pathways in tumors and validate the improvement parameters after natural products administration. The era of molecularly targeted therapy and personalized medicine is approaching and naturally occurring substances are very useful tools for tumor treatment and prevention. Plant extract substances have strong specificity and pertinence, are non- toxic and have few side effects, and may become an emerging cancer treatment. Keywords: vascular abnormalities, plants, plant extract, naturopathic treatment |
| first_indexed | 2024-03-08T16:10:19Z |
| format | Article |
| id | doaj.art-4631503953c74ee0884e4706b7f60076 |
| institution | Directory Open Access Journal |
| issn | 1179-9927 |
| language | English |
| last_indexed | 2024-03-08T16:10:19Z |
| publishDate | 2024-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Pediatric Health, Medicine and Therapeutics |
| spelling | doaj.art-4631503953c74ee0884e4706b7f600762024-01-07T18:06:44ZengDove Medical PressPediatric Health, Medicine and Therapeutics1179-99272024-01-01Volume 1511689556The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular TumorsRoca ICCojocaru ERusu CDTrandafir LMSăveanu CILupu VVButnariu LIŢarcă VMoscalu MBernic JLupu AŢarcă EIulia Cristina Roca,1,* Elena Cojocaru,2 Carmen Daniela Rusu,1 Laura Mihaela Trandafir,3 Cătălina Iulia Săveanu,4 Vasile Valeriu Lupu,3,* Lăcrămioara Ionela Butnariu,5 Viorel Ţarcă,6,* Mihaela Moscalu,6 Jana Bernic,7 Ancuța Lupu,3,* Elena Ţarcă1 1Department of Surgery II, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, 700115, Romania; 2Department of Morphofunctional Sciences I – Pathology, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, 700115, Romania; 3Department of Mother and Child Medicine–Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, 700115, Romania; 4Surgical Department, Discipline of Preventive Dentistry, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, 700115, Romania; 5Department of Medical Genetics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, 700115, Romania; 6Department of Preventive Medicine and Interdisciplinarity, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, 700115, Romania; 7Discipline of Pediatric Surgery, “Nicolae Testemițanu” State University of Medicine and Pharmacy, Chisinau, Moldova*These authors contributed equally to this workCorrespondence: Carmen Daniela Rusu; Cătălina Iulia Săveanu, Tel +40765485446, Email carmen-daniela.rusu@umfiasi.ro; catalina.saveanu@umfiasi.roAbstract: Hemangiomas are vascular tumors resulting from the proliferation of endothelial-like cells; they are the most common childhood tumors, affecting approximately 5– 10% of newborns and infants. Besides hemangiomas, which are definitely benign tumors despite their overgrowth potential, there are other vascular tumors like hemangioendotheliomas, which may display intermediate characteristics between benign hemangiomas and highly malignant angiosarcomas. Standard therapy may be constricted by serious adverse effects, high cost, or traumatic influence. Diet is a major resource for health preservation, disease prevention, and treatment. The therapeutic property of edible berries, marine products, or medicinal plants have long been known and used in traditional medicine; a plant-based nutrition can prevent the development and progression of diseases associated with extensive neo-vascularization. The purpose of our review is to highlight those natural treatments that hemangioma and vascular tumor patients can receive in the future, both for their benefit and that of their families. We performed the review according to the Preferred Reporting Items for Systematic Reviews and Metanalysis Statement. We used the Web of Science, PubMed, and EMBASE engines for the study, and searched for the association of hemangioma with naturopathic treatment/plant extract/plants in published articles. We found that natural extracts from plants and fruits are cost-effective and safe treatments for hemangiomas and vascular tumors, as well as for other forms of cancer. In any case, more in vitro and in vivo studies are needed to confirm the proposed signaling pathways in tumors and validate the improvement parameters after natural products administration. The era of molecularly targeted therapy and personalized medicine is approaching and naturally occurring substances are very useful tools for tumor treatment and prevention. Plant extract substances have strong specificity and pertinence, are non- toxic and have few side effects, and may become an emerging cancer treatment. Keywords: vascular abnormalities, plants, plant extract, naturopathic treatmenthttps://www.dovepress.com/the-role-of-natural-extracts-in-the-management-of-infantile-hemangioma-peer-reviewed-fulltext-article-PHMTvascular abnormalitiesplantsplant extractnaturopathic treatment |
| spellingShingle | Roca IC Cojocaru E Rusu CD Trandafir LM Săveanu CI Lupu VV Butnariu LI Ţarcă V Moscalu M Bernic J Lupu A Ţarcă E The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular Tumors Pediatric Health, Medicine and Therapeutics vascular abnormalities plants plant extract naturopathic treatment |
| title | The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular Tumors |
| title_full | The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular Tumors |
| title_fullStr | The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular Tumors |
| title_full_unstemmed | The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular Tumors |
| title_short | The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular Tumors |
| title_sort | role of natural extracts in the management of infantile hemangiomas and vascular tumors |
| topic | vascular abnormalities plants plant extract naturopathic treatment |
| url | https://www.dovepress.com/the-role-of-natural-extracts-in-the-management-of-infantile-hemangioma-peer-reviewed-fulltext-article-PHMT |
| work_keys_str_mv | AT rocaic theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT cojocarue theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT rusucd theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT trandafirlm theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT saveanuci theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT lupuvv theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT butnariuli theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT tarcav theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT moscalum theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT bernicj theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT lupua theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT tarcae theroleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT rocaic roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT cojocarue roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT rusucd roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT trandafirlm roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT saveanuci roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT lupuvv roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT butnariuli roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT tarcav roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT moscalum roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT bernicj roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT lupua roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors AT tarcae roleofnaturalextractsinthemanagementofinfantilehemangiomasandvasculartumors |