Evaluation of insulin resistance and beta-cell dysfunctions in newly diagnosed polycystic ovarian syndrome patients
Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing glucose intolerance and diabetes attributed to increased insulin resistance (IR). However, it is not clear whether β-cell dysfunction has a central role in pathogenesis. The distinction has important implic...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of the Scientific Society |
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| Online Access: | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2022;volume=49;issue=3;spage=260;epage=264;aulast=Ghatnatti |
| _version_ | 1797954786680635392 |
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| author | Vikrant Ghatnatti Shwetha Patil Harpreet Kour |
| author_facet | Vikrant Ghatnatti Shwetha Patil Harpreet Kour |
| author_sort | Vikrant Ghatnatti |
| collection | DOAJ |
| description | Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing glucose intolerance and diabetes attributed to increased insulin resistance (IR). However, it is not clear whether β-cell dysfunction has a central role in pathogenesis. The distinction has important implications for the prevention of type 2 diabetes in PCOS with interventions that ameliorate IR. This study aimed to find if IR differs among the various phenotypes of PCOS and perform a quantitative estimation of β-cell dysfunction versus IR in patients of PCOS participants. Materials and Methods: This case–control study was conducted for 1 year in the Endocrinology and Gynaecology outpatient departments at Gauhati Medical College. Fifty women newly diagnosed with PCOS, as per the Rotterdam criteria, were considered cases. Fifty, age- and body mass index-matched healthy females were taken as controls. Fasting and postprandial blood glucose, serum insulin, testosterone, and oral glucose tolerance test values were taken. Impaired fasting glucose, impaired glucose tolerance (IGT), and type 2 diabetes mellitus T2DM were diagnosed according to ADA 2011 criteria. IR and β-cell function were determined by “homeostasis model assessment (HOMA)”. Results: We observed an altered relationship between IR and insulin secretion, consistent with an intrinsic β-cell defect, wherein IR led to a decreased amount of compensatory insulin secretion in PCOS compared with normal women. The correlation coefficients relating HOMA%B to HOMA-IR were lower in PCOS, indicating less compensatory insulin secretion for a given increment in IR. Conclusion: PCOS patients are at increased risk of developing glucose intolerance and diabetes. |
| first_indexed | 2024-04-10T23:22:59Z |
| format | Article |
| id | doaj.art-4632cc68c9d745c7bd77a8bb79cbfe54 |
| institution | Directory Open Access Journal |
| issn | 0974-5009 |
| language | English |
| last_indexed | 2024-04-10T23:22:59Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Scientific Society |
| spelling | doaj.art-4632cc68c9d745c7bd77a8bb79cbfe542023-01-12T13:27:21ZengWolters Kluwer Medknow PublicationsJournal of the Scientific Society0974-50092022-01-0149326026410.4103/jss.jss_4_21Evaluation of insulin resistance and beta-cell dysfunctions in newly diagnosed polycystic ovarian syndrome patientsVikrant GhatnattiShwetha PatilHarpreet KourIntroduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing glucose intolerance and diabetes attributed to increased insulin resistance (IR). However, it is not clear whether β-cell dysfunction has a central role in pathogenesis. The distinction has important implications for the prevention of type 2 diabetes in PCOS with interventions that ameliorate IR. This study aimed to find if IR differs among the various phenotypes of PCOS and perform a quantitative estimation of β-cell dysfunction versus IR in patients of PCOS participants. Materials and Methods: This case–control study was conducted for 1 year in the Endocrinology and Gynaecology outpatient departments at Gauhati Medical College. Fifty women newly diagnosed with PCOS, as per the Rotterdam criteria, were considered cases. Fifty, age- and body mass index-matched healthy females were taken as controls. Fasting and postprandial blood glucose, serum insulin, testosterone, and oral glucose tolerance test values were taken. Impaired fasting glucose, impaired glucose tolerance (IGT), and type 2 diabetes mellitus T2DM were diagnosed according to ADA 2011 criteria. IR and β-cell function were determined by “homeostasis model assessment (HOMA)”. Results: We observed an altered relationship between IR and insulin secretion, consistent with an intrinsic β-cell defect, wherein IR led to a decreased amount of compensatory insulin secretion in PCOS compared with normal women. The correlation coefficients relating HOMA%B to HOMA-IR were lower in PCOS, indicating less compensatory insulin secretion for a given increment in IR. Conclusion: PCOS patients are at increased risk of developing glucose intolerance and diabetes.http://www.jscisociety.com/article.asp?issn=0974-5009;year=2022;volume=49;issue=3;spage=260;epage=264;aulast=Ghatnattidysglycemiaglucose toleranceinsulin sensitivitypolycystic ovary syndrometype 2 diabetes mellitusβ-cell function |
| spellingShingle | Vikrant Ghatnatti Shwetha Patil Harpreet Kour Evaluation of insulin resistance and beta-cell dysfunctions in newly diagnosed polycystic ovarian syndrome patients Journal of the Scientific Society dysglycemia glucose tolerance insulin sensitivity polycystic ovary syndrome type 2 diabetes mellitus β-cell function |
| title | Evaluation of insulin resistance and beta-cell dysfunctions in newly diagnosed polycystic ovarian syndrome patients |
| title_full | Evaluation of insulin resistance and beta-cell dysfunctions in newly diagnosed polycystic ovarian syndrome patients |
| title_fullStr | Evaluation of insulin resistance and beta-cell dysfunctions in newly diagnosed polycystic ovarian syndrome patients |
| title_full_unstemmed | Evaluation of insulin resistance and beta-cell dysfunctions in newly diagnosed polycystic ovarian syndrome patients |
| title_short | Evaluation of insulin resistance and beta-cell dysfunctions in newly diagnosed polycystic ovarian syndrome patients |
| title_sort | evaluation of insulin resistance and beta cell dysfunctions in newly diagnosed polycystic ovarian syndrome patients |
| topic | dysglycemia glucose tolerance insulin sensitivity polycystic ovary syndrome type 2 diabetes mellitus β-cell function |
| url | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2022;volume=49;issue=3;spage=260;epage=264;aulast=Ghatnatti |
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