Antimicrobial Oleogel Containing Sustainably Prepared Silver-Based Nanomaterials for Topical Application
Oleogels containing silica–silver-based nanomaterials were prepared to be used as potential antimicrobial treatment for preventing and curing skin infections. Fumed silica was used as a bifunctional excipient able to offer support to silver-based nanoparticle growth and act as a gelling agent for ol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/1/4 |
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| author | Valeria Ambrogi Morena Nocchetti Donatella Pietrella Giulia Quaglia Alessandro Di Michele Loredana Latterini |
| author_facet | Valeria Ambrogi Morena Nocchetti Donatella Pietrella Giulia Quaglia Alessandro Di Michele Loredana Latterini |
| author_sort | Valeria Ambrogi |
| collection | DOAJ |
| description | Oleogels containing silica–silver-based nanomaterials were prepared to be used as potential antimicrobial treatment for preventing and curing skin infections. Fumed silica was used as a bifunctional excipient able to offer support to silver-based nanoparticle growth and act as a gelling agent for oleogel formulation. First, silica–silver composites were prepared following a sustainable method by contact of fumed silica and silver nitrate in the presence of ethanol and successive UV irradiation. The composites were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), ATR FT-IR spectroscopy and UV-Vis spectrophotometry. The presence of 8–20 nm spherical nanoparticles, in addition to the silica aggregates and AgNO<sub>3</sub> crystals, was detected. The composites showed good antimicrobial activity against the Gram-negative <i>Pseudomonas aeruginosa</i> and the Gram-positive bacteria <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>. Thus, they were formulated in an oleogel, obtained using fumed silica as a gelling agent. For comparison, oleogels containing AgNO<sub>3</sub> were prepared according to two different formulative techniques. The silica–silver-based oleogels showed good antimicrobial activity and did not show cytotoxic effects for fibroblasts and keratinocytes. |
| first_indexed | 2024-03-08T10:46:06Z |
| format | Article |
| id | doaj.art-4636ae6cb4e6420fb405ef8de153267a |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-08T10:46:06Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-4636ae6cb4e6420fb405ef8de153267a2024-01-26T17:10:53ZengMDPI AGJournal of Functional Biomaterials2079-49832023-12-01151410.3390/jfb15010004Antimicrobial Oleogel Containing Sustainably Prepared Silver-Based Nanomaterials for Topical ApplicationValeria Ambrogi0Morena Nocchetti1Donatella Pietrella2Giulia Quaglia3Alessandro Di Michele4Loredana Latterini5Dipartimento di Scienze Farmaceutiche, University of Perugia, Via del Liceo 1, 06123 Perugia, ItalyDipartimento di Scienze Farmaceutiche, University of Perugia, Via del Liceo 1, 06123 Perugia, ItalyNano4Light Lab, Dipartimento di Chimica, Biologia e Biotecnologie, University of Perugia, Via Elce di Sotto 8, 06123 Perugia, ItalyDipartimento di Medicina e Chirurgia, University of Perugia, Piazzale Lucio Severi 1, 06129 Perugia, ItalyDipartimento di Fisica e Geologia, University of Perugia, Via Pascoli, 06123 Perugia, ItalyDipartimento di Medicina e Chirurgia, University of Perugia, Piazzale Lucio Severi 1, 06129 Perugia, ItalyOleogels containing silica–silver-based nanomaterials were prepared to be used as potential antimicrobial treatment for preventing and curing skin infections. Fumed silica was used as a bifunctional excipient able to offer support to silver-based nanoparticle growth and act as a gelling agent for oleogel formulation. First, silica–silver composites were prepared following a sustainable method by contact of fumed silica and silver nitrate in the presence of ethanol and successive UV irradiation. The composites were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), ATR FT-IR spectroscopy and UV-Vis spectrophotometry. The presence of 8–20 nm spherical nanoparticles, in addition to the silica aggregates and AgNO<sub>3</sub> crystals, was detected. The composites showed good antimicrobial activity against the Gram-negative <i>Pseudomonas aeruginosa</i> and the Gram-positive bacteria <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>. Thus, they were formulated in an oleogel, obtained using fumed silica as a gelling agent. For comparison, oleogels containing AgNO<sub>3</sub> were prepared according to two different formulative techniques. The silica–silver-based oleogels showed good antimicrobial activity and did not show cytotoxic effects for fibroblasts and keratinocytes.https://www.mdpi.com/2079-4983/15/1/4silver nanomaterialsoleogelantimicrobial and antibiofilm activitiescytotoxicity |
| spellingShingle | Valeria Ambrogi Morena Nocchetti Donatella Pietrella Giulia Quaglia Alessandro Di Michele Loredana Latterini Antimicrobial Oleogel Containing Sustainably Prepared Silver-Based Nanomaterials for Topical Application Journal of Functional Biomaterials silver nanomaterials oleogel antimicrobial and antibiofilm activities cytotoxicity |
| title | Antimicrobial Oleogel Containing Sustainably Prepared Silver-Based Nanomaterials for Topical Application |
| title_full | Antimicrobial Oleogel Containing Sustainably Prepared Silver-Based Nanomaterials for Topical Application |
| title_fullStr | Antimicrobial Oleogel Containing Sustainably Prepared Silver-Based Nanomaterials for Topical Application |
| title_full_unstemmed | Antimicrobial Oleogel Containing Sustainably Prepared Silver-Based Nanomaterials for Topical Application |
| title_short | Antimicrobial Oleogel Containing Sustainably Prepared Silver-Based Nanomaterials for Topical Application |
| title_sort | antimicrobial oleogel containing sustainably prepared silver based nanomaterials for topical application |
| topic | silver nanomaterials oleogel antimicrobial and antibiofilm activities cytotoxicity |
| url | https://www.mdpi.com/2079-4983/15/1/4 |
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