Physiological and histological effects of apigenin and luteolin on Cytarabine injected rats
The present study was undertaken to study the effect of apigenin and luteolin on physiological and histological changes in rats treated with cytarabine drugs. Thirty-five albino healthy male adult rats with equal age weighing 250 -300g were enrolled. Rats were randomly divided into seven g...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2024-01-01
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| Series: | Baghdad Science Journal |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7000 |
| _version_ | 1827390711423565824 |
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| author | Ghada A. Taqa Omar N. Sultan |
| author_facet | Ghada A. Taqa Omar N. Sultan |
| author_sort | Ghada A. Taqa |
| collection | DOAJ |
| description |
The present study was undertaken to study the effect of apigenin and luteolin on physiological and histological changes in rats treated with cytarabine drugs. Thirty-five albino healthy male adult rats with equal age weighing 250 -300g were enrolled. Rats were randomly divided into seven groups according to the treatment. Group “1” was treated with normal saline and served as the control group. Groups “2,3 and 4” received cytarabine, apigenin, and luteolin respectively, while groups 5, 6, and 7 received a combination of “apigenin + cytarabine”, “luteolin + cytarabine”, and “apigenin + luteolin + cytarabine”, respectively. After one week of treatment, all seven groups of rats were sacrificed for histological finding, and blood samples were collected from each rat for biochemical parameters analysis. The results of this study showed that cytarabine increased the activity of GPT, GOT, and cholesterol levels in rats after one week of intraperitoneal injection in comparison to the control. There was no significant difference in GPT and GOT when apigenin and luteolin were administrated orally compared to the control group. When apigenin and luteolin are combined with cytarabine, they have a protective effect on leakage of liver enzymes GPT and GOT in serum. Apigenin and luteolin histologically protect liver cells from cytarabine damage when administered alone. These findings conclude that apigenin and luteolin have a protective effect on cytarabine side effects on the liver and its function in rats.
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| first_indexed | 2024-03-08T16:56:42Z |
| format | Article |
| id | doaj.art-4638321e7b5e4a40aaf78e44f07b66a6 |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-03-08T16:56:42Z |
| publishDate | 2024-01-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-4638321e7b5e4a40aaf78e44f07b66a62024-01-04T20:03:09ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862024-01-0121110.21123/bsj.2023.7000Physiological and histological effects of apigenin and luteolin on Cytarabine injected ratsGhada A. Taqa0Omar N. Sultan1Department of Dental Basic Sciences, College of Dentistry, University of Mosul, Mosul, Iraq.Department of Dental Basic Sciences, College of Dentistry, University of Mosul, Mosul, Iraq. The present study was undertaken to study the effect of apigenin and luteolin on physiological and histological changes in rats treated with cytarabine drugs. Thirty-five albino healthy male adult rats with equal age weighing 250 -300g were enrolled. Rats were randomly divided into seven groups according to the treatment. Group “1” was treated with normal saline and served as the control group. Groups “2,3 and 4” received cytarabine, apigenin, and luteolin respectively, while groups 5, 6, and 7 received a combination of “apigenin + cytarabine”, “luteolin + cytarabine”, and “apigenin + luteolin + cytarabine”, respectively. After one week of treatment, all seven groups of rats were sacrificed for histological finding, and blood samples were collected from each rat for biochemical parameters analysis. The results of this study showed that cytarabine increased the activity of GPT, GOT, and cholesterol levels in rats after one week of intraperitoneal injection in comparison to the control. There was no significant difference in GPT and GOT when apigenin and luteolin were administrated orally compared to the control group. When apigenin and luteolin are combined with cytarabine, they have a protective effect on leakage of liver enzymes GPT and GOT in serum. Apigenin and luteolin histologically protect liver cells from cytarabine damage when administered alone. These findings conclude that apigenin and luteolin have a protective effect on cytarabine side effects on the liver and its function in rats. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7000Apigenin, Cholesterol, Cytarabine, Liver enzymes, Luteolin |
| spellingShingle | Ghada A. Taqa Omar N. Sultan Physiological and histological effects of apigenin and luteolin on Cytarabine injected rats Baghdad Science Journal Apigenin, Cholesterol, Cytarabine, Liver enzymes, Luteolin |
| title | Physiological and histological effects of apigenin and luteolin on Cytarabine injected rats |
| title_full | Physiological and histological effects of apigenin and luteolin on Cytarabine injected rats |
| title_fullStr | Physiological and histological effects of apigenin and luteolin on Cytarabine injected rats |
| title_full_unstemmed | Physiological and histological effects of apigenin and luteolin on Cytarabine injected rats |
| title_short | Physiological and histological effects of apigenin and luteolin on Cytarabine injected rats |
| title_sort | physiological and histological effects of apigenin and luteolin on cytarabine injected rats |
| topic | Apigenin, Cholesterol, Cytarabine, Liver enzymes, Luteolin |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7000 |
| work_keys_str_mv | AT ghadaataqa physiologicalandhistologicaleffectsofapigeninandluteolinoncytarabineinjectedrats AT omarnsultan physiologicalandhistologicaleffectsofapigeninandluteolinoncytarabineinjectedrats |