Mitochondrial Control in Inflammatory Gastrointestinal Diseases
Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of mu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/23/14890 |
| _version_ | 1797463067709145088 |
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| author | Guo-Yan Sui Feng Wang Jin Lee Yoon Seok Roh |
| author_facet | Guo-Yan Sui Feng Wang Jin Lee Yoon Seok Roh |
| author_sort | Guo-Yan Sui |
| collection | DOAJ |
| description | Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of multiple inflammatory signaling pathways, leading to IBD and increased severity of CRC. In this review, we focus on the mitochondria and inflammatory signaling pathways and its related gastrointestinal diseases. |
| first_indexed | 2024-03-09T17:45:22Z |
| format | Article |
| id | doaj.art-463987cbf90344a5829b59d7a36bbc2b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T17:45:22Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-463987cbf90344a5829b59d7a36bbc2b2023-11-24T11:09:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123231489010.3390/ijms232314890Mitochondrial Control in Inflammatory Gastrointestinal DiseasesGuo-Yan Sui0Feng Wang1Jin Lee2Yoon Seok Roh3College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of KoreaCollege of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of KoreaDepartment of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USACollege of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of KoreaMitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of multiple inflammatory signaling pathways, leading to IBD and increased severity of CRC. In this review, we focus on the mitochondria and inflammatory signaling pathways and its related gastrointestinal diseases.https://www.mdpi.com/1422-0067/23/23/14890mitochondriabiogenesismitophagyinflammatory bowel diseasecolorectal cancer |
| spellingShingle | Guo-Yan Sui Feng Wang Jin Lee Yoon Seok Roh Mitochondrial Control in Inflammatory Gastrointestinal Diseases International Journal of Molecular Sciences mitochondria biogenesis mitophagy inflammatory bowel disease colorectal cancer |
| title | Mitochondrial Control in Inflammatory Gastrointestinal Diseases |
| title_full | Mitochondrial Control in Inflammatory Gastrointestinal Diseases |
| title_fullStr | Mitochondrial Control in Inflammatory Gastrointestinal Diseases |
| title_full_unstemmed | Mitochondrial Control in Inflammatory Gastrointestinal Diseases |
| title_short | Mitochondrial Control in Inflammatory Gastrointestinal Diseases |
| title_sort | mitochondrial control in inflammatory gastrointestinal diseases |
| topic | mitochondria biogenesis mitophagy inflammatory bowel disease colorectal cancer |
| url | https://www.mdpi.com/1422-0067/23/23/14890 |
| work_keys_str_mv | AT guoyansui mitochondrialcontrolininflammatorygastrointestinaldiseases AT fengwang mitochondrialcontrolininflammatorygastrointestinaldiseases AT jinlee mitochondrialcontrolininflammatorygastrointestinaldiseases AT yoonseokroh mitochondrialcontrolininflammatorygastrointestinaldiseases |