Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated review
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) appeared in early 2019 and swiftly became a pandemic causing extensive morbidity and mortality. Many studies have recognized the neuropathological changes in the brain and hypothe...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-07-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-023-00705-8 |
| _version_ | 1797774274919923712 |
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| author | Srinagesh Mannekote Thippaiah Shabbir Amanullah Zi Huai Huang Edward Goldschmidt Basant Pradhan |
| author_facet | Srinagesh Mannekote Thippaiah Shabbir Amanullah Zi Huai Huang Edward Goldschmidt Basant Pradhan |
| author_sort | Srinagesh Mannekote Thippaiah |
| collection | DOAJ |
| description | Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) appeared in early 2019 and swiftly became a pandemic causing extensive morbidity and mortality. Many studies have recognized the neuropathological changes in the brain and hypothesized the possible link with cognitive dysfunction, neuropsychiatric symptoms and behavioral disturbances. Potential biological mechanisms may include direct neuronal micro-invasion, disturbances in the neuro-immuno-endocrine system and possibly alteration of neuronal excitability. SARS-CoV-2 facilitates down-regulation of the ACE2 (Angiotensin-2) receptors which could alter inflammatory response through various cellular and neurophysiological systems leading to disturbance in the hypo-thalamopituitary–adrenal (HPA) axis, escalation of the oxidative stress and disruption of the homeostasis of the neurotransmitter system, including serotonin, dopamine and GABA (gamma-aminobutyric acid), eventually resulting in the emergence of neuropsychiatric symptoms. Psychiatric symptoms that emerged are many, some of which may be unique to SARS-CoV-2 infection. These neuropsychiatric symptoms are acute or chronic with possibly distinct etiopathogenesis. This article discusses the possible biological correlates and neurobiology of the psychiatric symptoms of SARS-CoV-2 and their impact on the brain and behavior. |
| first_indexed | 2024-03-12T22:18:41Z |
| format | Article |
| id | doaj.art-463ce97d0f144a3ba5693e57af5bf97f |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-03-12T22:18:41Z |
| publishDate | 2023-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-463ce97d0f144a3ba5693e57af5bf97f2023-07-23T11:09:37ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292023-07-0159111310.1186/s41983-023-00705-8Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated reviewSrinagesh Mannekote Thippaiah0Shabbir Amanullah1Zi Huai Huang2Edward Goldschmidt3Basant Pradhan4Creighton University School of MedicineWoodstock GeneralDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western UniversityCooper Medical School of Rowan UniversityCooper Medical School of Rowan UniversityAbstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) appeared in early 2019 and swiftly became a pandemic causing extensive morbidity and mortality. Many studies have recognized the neuropathological changes in the brain and hypothesized the possible link with cognitive dysfunction, neuropsychiatric symptoms and behavioral disturbances. Potential biological mechanisms may include direct neuronal micro-invasion, disturbances in the neuro-immuno-endocrine system and possibly alteration of neuronal excitability. SARS-CoV-2 facilitates down-regulation of the ACE2 (Angiotensin-2) receptors which could alter inflammatory response through various cellular and neurophysiological systems leading to disturbance in the hypo-thalamopituitary–adrenal (HPA) axis, escalation of the oxidative stress and disruption of the homeostasis of the neurotransmitter system, including serotonin, dopamine and GABA (gamma-aminobutyric acid), eventually resulting in the emergence of neuropsychiatric symptoms. Psychiatric symptoms that emerged are many, some of which may be unique to SARS-CoV-2 infection. These neuropsychiatric symptoms are acute or chronic with possibly distinct etiopathogenesis. This article discusses the possible biological correlates and neurobiology of the psychiatric symptoms of SARS-CoV-2 and their impact on the brain and behavior.https://doi.org/10.1186/s41983-023-00705-8NeurotransmittersNeuro-immuno dysregulationbiological correlatesPsychiatric symptomsSARS-CoV-2 |
| spellingShingle | Srinagesh Mannekote Thippaiah Shabbir Amanullah Zi Huai Huang Edward Goldschmidt Basant Pradhan Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated review The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Neurotransmitters Neuro-immuno dysregulation biological correlates Psychiatric symptoms SARS-CoV-2 |
| title | Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated review |
| title_full | Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated review |
| title_fullStr | Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated review |
| title_full_unstemmed | Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated review |
| title_short | Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated review |
| title_sort | biological correlates of the neuropsychiatric symptoms in sars cov 2 infection an updated review |
| topic | Neurotransmitters Neuro-immuno dysregulation biological correlates Psychiatric symptoms SARS-CoV-2 |
| url | https://doi.org/10.1186/s41983-023-00705-8 |
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