MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model

MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model

This study aimed to determine whether microRNA-322-5p regulates seizure and seizure damage by targeting the TLR4/TRAF6/NF-κB-associated inflammatory signaling pathway. In a pilocarpine-induced epileptic rat model, the expressions of miR-322-5p, TLR4, NF-κB, TRAF6, IRF5, IL-1β, and GABA were assessed...

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Bibliographic Details
Main Authors: Zhou Qin, Wang Qiong, He Baomei, Kong Haibo, Luo Huanjun, Wang Xiaowei, Wang Wenlan
Format: Article
Language:English
Published: De Gruyter 2022-05-01
Series:Open Medicine
Subjects:
epilepsy
inflammation
mir-322-5p
traf6
nf-κb
apoptosis
Online Access:https://doi.org/10.1515/med-2022-0485

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